Pathological Findings of Postmortem Biopsies From Lung, Heart, and Liver of 7 Deceased COVID-19 Patients.
Pathological Findings of Postmortem Biopsies From Lung, Heart, and Liver of 7 Deceased COVID-19 Patients.
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DOI：
10.1177/1066896920935195
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发表时间：
2021-04
影响因子：
1.2
通讯作者：
Abdollahi A
中科院分区：
文献类型：
--
作者：
Beigmohammadi MT;Jahanbin B;Safaei M;Amoozadeh L;Khoshavi M;Mehrtash V;Jafarzadeh B;Abdollahi A
背景。一种名为严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 的新型冠状病毒已经影响到世界上几乎所有国家。大多数住进重症监护室的感染者都表现出SARS症状。在这项研究中，我们的目的是更好地了解新型冠状病毒感染期间大多数假定受影响的器官发生的病理变化。方法。我们对 7 名死于 2019 年冠状病毒病的患者进行了尸检，对肺、心脏和肝脏进行了尸检。准备好的组织切片由 2 名病理学家进行观察。结果。弥漫性肺泡损伤是肺组织样本中的主要病理发现。住院时间超过10天的患者表现出组织迹象。肺泡腔和肺泡壁中的多核细胞、非典型增大的细胞、肺泡腔中巨噬细胞的积聚以及血管通道充血是肺的其他组织病理学改变。我们的心脏活检样本均不符合心肌炎的标准。大多数情况下，肝活检显示充血、微泡和大泡改变以及轻微至轻度的门静脉炎症。结论。与2003年的冠状病毒感染类似，肺部的主要病理发现是弥漫性肺泡损伤，并在长期病例中出现组织模式。 SARS-CoV-2感染不会引起心肌炎，心肌缺血是观察到的心脏病理变化最可能的原因。肝组织切片大多显示非特异性发现；然而，在某些情况下可以发现肝脏缺血。
Background. A novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been affecting almost all nations around the world. Most infected patients who have been admitted to intensive care units show SARS signs. In this study, we aimed to achieve a better understanding of pathological alterations that take place during the novel coronavirus infection in most presumed affected organs. Methods. We performed postmortem core needle biopsies from lung, heart, and liver on 7 deceased patients who had died of coronavirus disease 2019. Prepared tissue sections were observed by 2 expert pathologists. Results. Diffuse alveolar damage was the main pathologic finding in the lung tissue samples. Patients with hospitalization durations of more than 10 days showed evidence of organization. Multinucleated cells in alveolar spaces and alveolar walls, atypical enlarged cells, accumulation of macrophages in alveolar spaces, and congestion of vascular channels were the other histopathologic alteration of the lung. None of our heart biopsy samples met the criteria for myocarditis. Liver biopsies showed congestion, micro- and macro-vesicular changes, and minimal to mild portal inflammation, in the majority of cases. Conclusions. Similar to the previous coronavirus infection in 2003, the main pathologic finding in the lung was diffuse alveolar damage with a pattern of organization in prolonged cases. The SARS-CoV-2 infection does not cause myocarditis, and the ischemia of myocardium is the most probable justification of the observed pathologic changes in the heart. Liver tissue sections mostly showed nonspecific findings; however, ischemia of the liver can be identified in some cases.
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DOI：
10.1016/j.ajpath.2015.10.024
发表时间：
2016-03
期刊：
The American journal of pathology
影响因子：
--
作者：
Ng DL;Al Hosani F;Keating MK;Gerber SI;Jones TL;Metcalfe MG;Tong S;Tao Y;Alami NN;Haynes LM;Mutei MA;Abdel-Wareth L;Uyeki TM;Swerdlow DL;Barakat M;Zaki SR
通讯作者：
Zaki SR
影响因子：
3.1
作者：
Darnell ME;Subbarao K;Feinstone SM;Taylor DR
通讯作者：
Taylor DR
影响因子：
13.5
作者：
Chau, TN;Lee, KC;Lai, CL
通讯作者：
Lai, CL
影响因子：
3.3
作者：
Ng WF;To KF;Lam WW;Ng TK;Lee KC
通讯作者：
Lee KC
DOI：
10.1016/s0140-6736(03)13413-7
发表时间：
2003-05-24
期刊：
Lancet (London, England)
影响因子：
--
作者：
Nicholls JM;Poon LL;Lee KC;Ng WF;Lai ST;Leung CY;Chu CM;Hui PK;Mak KL;Lim W;Yan KW;Chan KH;Tsang NC;Guan Y;Yuen KY;Peiris JS
通讯作者：
Peiris JS