The comparative pathology of severe acute respiratory syndrome and avian influenza A subtype H5N1--a review.
The comparative pathology of severe acute respiratory syndrome and avian influenza A subtype H5N1--a review.
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DOI：
10.1016/j.humpath.2006.01.015
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发表时间：
2006-04
期刊：
影响因子：
3.3
通讯作者：
Lee KC
中科院分区：
文献类型：
--
作者：
Ng WF;To KF;Lam WW;Ng TK;Lee KC
本文结合文献和病例，对近年来出现的两种人畜共患病毒感染，即冠状病毒引起的严重急性呼吸道综合征（SARS）和禽流感A亚型H5N1的病理学进行了综述和比较。肺细胞是感染的主要目标，导致弥漫性肺泡损伤。全身性细胞因子激活导致噬血细胞综合征、淋巴耗竭和骨骼肌纤维坏死。严重急性呼吸综合征诱导更多的纤维细胞肺泡内组织，具有“闭塞性细支气管炎机化性肺炎”样模式，并存在多核组织细胞和肺细胞。H5N1引起更暴发性和坏死性弥漫性肺泡损伤，伴有斑片状和间质性少细胞纤维化。严重急性呼吸系统综合征相关冠状病毒在肺部持续存在长达第二个月，而H5N1在肺部持续存在长达第三周。严重急性呼吸综合征相关冠状病毒可传播至血液、尿液、粪便、胃肠道和肝脏。最近有报告称H5N1可能累及大脑，并在血液、胃肠道和脑脊液中分离出H5N1。迫切需要更多的病理学研究。
The pathology of 2 zoonotic human viral infections that recently emerged, severe acute respiratory syndrome (SARS) due to coronavirus (SARS-CoV) and avian influenza A subtype H5N1, is reviewed and compared based on the literature and the cases examined by the authors. Pneumocytes are the primary target of infection resulting in diffuse alveolar damage. Systemic cytokine activation results in hemophagocytic syndrome, lymphoid depletion, and skeletal muscle fiber necrosis. Severe acute respiratory syndrome induces a more fibrocellular intra-alveolar organization with a “bronchiolitis obliterans organizing pneumonia”–like pattern and presence of multinucleated histiocytes and pneumocytes. H5N1 causes a more fulminant and necrotizing diffuse alveolar damage with patchy and interstitial paucicellular fibrosis. Severe acute respiratory syndrome associated coronavirus persists in the lung up to the second month, whereas H5N1 persists in the lung up to the third week. Severe acute respiratory syndrome associated coronavirus disseminates to blood, urine, feces, gastrointestinal tract, and liver. There is recent report of possible cerebral involvement by H5N1 and its isolation in the blood, gastrointestinal tract, and cerebrospinal fluid. More pathologic studies are urgently needed.
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影响因子：
11.8
作者：
Uiprasertkul M;Puthavathana P;Sangsiriwut K;Pooruk P;Srisook K;Peiris M;Nicholls JM;Chokephaibulkit K;Vanprapar N;Auewarakul P
通讯作者：
Auewarakul P
影响因子：
19.6
作者：
Chu KH;Tsang WK;Tang CS;Lam MF;Lai FM;To KF;Fung KS;Tang HL;Yan WW;Chan HW;Lai TS;Tong KL;Lai KN
通讯作者：
Lai KN
影响因子：
158.5
作者：
de Jong, MD;Van Cam, B;Farrar, J
通讯作者：
Farrar, J
影响因子：
5.4
作者：
Sturm-Ramirez, KM;Ellis, T;Webster, RG
通讯作者：
Webster, RG
影响因子：
3.3
作者：
Franks TJ;Chong PY;Chui P;Galvin JR;Lourens RM;Reid AH;Selbs E;McEvoy CP;Hayden CD;Fukuoka J;Taubenberger JK;Travis WD
通讯作者：
Travis WD