Spinal Inhibitory Interneurons: Gatekeepers of Sensorimotor Pathways.
Spinal Inhibitory Interneurons: Gatekeepers of Sensorimotor Pathways.
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DOI：
10.3390/ijms22052667
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发表时间：
2021-03-06
影响因子：
5.6
通讯作者：
Dougherty KJ
中科院分区：
文献类型：
--
作者：
Stachowski NJ;Dougherty KJ
感知和在环境中移动的能力是几乎所有物种生存所必需的复杂功能。脊髓既是外周信息的初始进入部位，也是运动反应的最终输出部位，脊髓回路在调节感觉反应和协调运动方面起着至关重要的作用。这部分是通过激活复杂的脊髓微电路来实现的，该电路对传入信号进行选通，以过滤来自各种感觉模式的外部刺激，并确定哪些信号被传递到中枢神经系统的高级结构和脊髓运动通路。对脊髓内抑制性中间神经元如何组织和使用的机械性理解将为针对包括感觉和运动障碍在内的各种病理基础的抑制性缺陷的治疗提供潜在的切入点。最近使用转基因操作、神经化学图谱和单细胞转录组的研究已经确定了不同的抑制性中间神经元群体，它们表达一系列构成功能微电路的遗传和/或神经化学标记。在这篇综述中，我们提供了已识别的组成脊髓背侧和腹侧微电路的神经成分的概述，并强调了在脊髓水平抑制控制感觉运动通路的重要性。
The ability to sense and move within an environment are complex functions necessary for the survival of nearly all species. The spinal cord is both the initial entry site for peripheral information and the final output site for motor response, placing spinal circuits as paramount in mediating sensory responses and coordinating movement. This is partly accomplished through the activation of complex spinal microcircuits that gate afferent signals to filter extraneous stimuli from various sensory modalities and determine which signals are transmitted to higher order structures in the CNS and to spinal motor pathways. A mechanistic understanding of how inhibitory interneurons are organized and employed within the spinal cord will provide potential access points for therapeutics targeting inhibitory deficits underlying various pathologies including sensory and movement disorders. Recent studies using transgenic manipulations, neurochemical profiling, and single-cell transcriptomics have identified distinct populations of inhibitory interneurons which express an array of genetic and/or neurochemical markers that constitute functional microcircuits. In this review, we provide an overview of identified neural components that make up inhibitory microcircuits within the dorsal and ventral spinal cord and highlight the importance of inhibitory control of sensorimotor pathways at the spinal level.
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DOI：
10.1126/science.aac8653
发表时间：
2015-10-30
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bourane S;Duan B;Koch SC;Dalet A;Britz O;Garcia-Campmany L;Kim E;Cheng L;Ghosh A;Ma Q;Goulding M
通讯作者：
Goulding M
影响因子：
5.2
作者：
Bardoni R;Takazawa T;Tong CK;Choudhury P;Scherrer G;Macdermott AB
通讯作者：
Macdermott AB
影响因子：
64.8
作者：
Andersson, Lisa S.;Larhammar, Martin;Memic, Fatima;Wootz, Hanna;Schwochow, Doreen;Rubin, Carl-Johan;Patra, Kalicharan;Arnason, Thorvaldur;Wellbring, Lisbeth;Hjalm, Goran;Imsland, Freyja;Petersen, Jessica L.;McCue, Molly E.;Mickelson, James R.;Cothran, Gus;Ahituv, Nadav;Roepstorff, Lars;Mikko, Sofia;Vallstedt, Anna;Lindgren, Gabriella;Andersson, Leif;Kullander, Klas
通讯作者：
Kullander, Klas
DOI：
10.1073/pnas.1419045111
发表时间：
2014-11-25
影响因子：
11.1
作者：
Akay, Turgay;Tourtellotte, Warren G.;Jessell, Thomas M.
通讯作者：
Jessell, Thomas M.
影响因子：
11.4
作者：
André, E;Conquet, F;Becker-André, M
通讯作者：
Becker-André, M