Low- q Bicelles Are Mixed Micelles.
Low- q Bicelles Are Mixed Micelles.
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DOI:
10.1021/acs.jpclett.8b02079
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发表时间:
2018-08-02
期刊:
影响因子:
--
通讯作者:
Columbus L
中科院分区:
文献类型:
--
作者:
Caldwell TA;Baoukina S;Brock AT;Oliver RC;Root KT;Krueger JK;Glover KJ;Tieleman DP;Columbus L
Bicelles are used in many membrane protein studies because they are thought to be more bilayer-like than micelles. We investigated the properties of “isotropic” bicelles by small-angle neutron scattering, small-angle X-ray scattering, fluorescence anisotropy, and molecular dynamics. All data suggest that bicelles with a q value below 1 deviate from the classic bicelle that contains lipids in the core and detergent in the rim. Thus not all isotropic bicelles are bilayer-like.
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