Effects of Resveratrol on the Renin-Angiotensin System in the Aging Kidney.
Effects of Resveratrol on the Renin-Angiotensin System in the Aging Kidney.
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白藜芦醇对肾脏肾脏肾素 - 血管紧张素系统的影响。
DOI：
10.3390/nu10111741
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发表时间：
2018-11-12
期刊：
影响因子：
5.9
通讯作者：
Choi BS
中科院分区：
文献类型：
--
作者：
Jang IA;Kim EN;Lim JH;Kim MY;Ban TH;Yoon HE;Park CW;Chang YS;Choi BS
肾素-血管紧张素系统（RAS），特别是血管紧张素II（Ang II）/血管紧张素II 1型受体（AT 1 R）轴，通过增加组织活性氧产生和进行性增加氧化应激在肾脏的衰老过程中起重要作用。相反，血管紧张素1-7（Ang 1-7）/Mas受体（MasR）轴，其抵消Ang II的作用，对终末器官损伤具有保护作用。为了评估白藜芦醇（RSV）调节衰老肾脏中RAS的能力，将18个月大的雄性C57 BL/6小鼠分成两组，接受正常小鼠食物或含有白藜芦醇的食物，持续6个月。肾RAS组分的表达，以及前和抗氧化酶，进行了测量和小鼠肾脏分离的组织病理学。白藜芦醇治疗的小鼠表现出更好的肾功能和减少白蛋白尿，改善肾脏组织学检查结果。白藜芦醇抑制Ang Ⅱ/AT 1 R轴，增强AT 2 R/Ang 1-7/MasR轴。此外，白藜芦醇处理还可降低烟酰胺腺嘌呤二核苷酸磷酸氧化酶4，8-羟基-2 ′-脱氧鸟苷、3-硝基酪氨酸、IV型胶原和纤连蛋白的表达，而增加内皮型一氧化氮合酶和超氧化物歧化酶2的表达。这些发现表明，白藜芦醇通过抑制血管紧张素II和激活MasR，减少氧化应激，炎症和纤维化，对衰老的肾脏发挥保护作用。
The renin-angiotensin system (RAS), especially the angiotensin II (Ang II)/angiotensin II type 1 receptor (AT1R) axis, plays an important role in the aging process of the kidney, through increased tissue reactive oxygen species production and progressively increased oxidative stress. In contrast, the angiotensin 1-7 (Ang 1-7)/Mas receptor (MasR) axis, which counteracts the effects of Ang II, is protective for end-organ damage. To evaluate the ability of resveratrol (RSV) to modulate the RAS in aging kidneys, eighteen-month-old male C57BL/6 mice were divided into two groups that received either normal mouse chow or chow containing resveratrol, for six months. Renal expressions of RAS components, as well as pro- and antioxidant enzymes, were measured and mouse kidneys were isolated for histopathology. Resveratrol-treated mice demonstrated better renal function and reduced albuminuria, with improved renal histologic findings. Resveratrol suppressed the Ang II/AT1R axis and enhanced the AT2R/Ang 1-7/MasR axis. Additionally, the expression of nicotinamide adenine dinucleotide phosphate oxidase 4, 8-hydroxy-2′-deoxyguanosine, 3-nitrotyrosine, collagen IV, and fibronectin was decreased, while the expression of endothelial nitric oxide synthase and superoxide dismutase 2 was increased by resveratrol treatment. These findings demonstrate that resveratrol exerts protective effects on aging kidneys by reducing oxidative stress, inflammation, and fibrosis, through Ang II suppression and MasR activation.
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DOI：
10.1042/cs20120190
发表时间：
2013-02
期刊：
Clinical science (London, England : 1979)
影响因子：
--
作者：
Kitada M;Kume S;Takeda-Watanabe A;Kanasaki K;Koya D
通讯作者：
Koya D
Sirtuins是否可行的目标可以改善健康状态和寿命？
DOI：
10.1038/nrd3738
发表时间：
2012-06-01
期刊：
Nature reviews. Drug discovery
影响因子：
--
作者：
Baur JA;Ungvari Z;Minor RK;Le Couteur DG;de Cabo R
通讯作者：
de Cabo R
影响因子：
--
作者：
Kitada M;Koya D
通讯作者：
Koya D
影响因子：
2.7
作者：
Fazeli, Gholamreza;Stopper, Helga;Schupp, Nicole
通讯作者：
Schupp, Nicole
DOI：
10.18632/aging.101419
发表时间：
2018-04-17
期刊：
Aging
影响因子：
--
作者：
Jiang T;Xue LJ;Yang Y;Wang QG;Xue X;Ou Z;Gao Q;Shi JQ;Wu L;Zhang YD
通讯作者：
Zhang YD