Synergistic effects of free radical scavengers and cochlear vasodilators: a new otoprotective strategy for age-related hearing loss.
Synergistic effects of free radical scavengers and cochlear vasodilators: a new otoprotective strategy for age-related hearing loss.
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DOI：
10.3389/fnagi.2015.00086
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发表时间：
2015
影响因子：
4.8
通讯作者：
Juiz JM
中科院分区：
文献类型：
--
作者：
Alvarado JC;Fuentes-Santamaría V;Melgar-Rojas P;Valero ML;Gabaldón-Ull MC;Miller JM;Juiz JM
年龄相关性听力损失(ARHL)的日益增加，其生活质量的急剧下降和医疗费用的显著增加，是开发新的治疗策略以预防或减少这种与衰老相关的疾病的催化剂。在这方面，有广泛的证据表明，过度的自由基形成和耳蜗血流量减少是其他应激相关听力损失机制的基本因素，如与噪音或耳毒性药物暴露有关的机制。新的观点认为两者在ARHL的发病机制中都起着关键作用。针对过度的自由基形成和耳蜗血流量调节的治疗靶向可能是预防ARHL发病的有效策略。支持这一观点的是，基于微量营养素的疗法，特别是那些结合抗氧化剂和血管扩张剂(如镁(Mg2+))的疗法，已被证明在减少噪音和耳毒性药物对内耳的影响方面有效，从而改善听觉功能。在这篇综述中，我们将讨论抗氧化自由基清除剂和耳蜗血管扩张剂的协同作用，作为一种可行的治疗ARHL的方法。
The growing increase in age-related hearing loss (ARHL), with its dramatic reduction in quality of life and significant increase in health care costs, is a catalyst to develop new therapeutic strategies to prevent or reduce this aging-associated condition. In this regard, there is extensive evidence that excessive free radical formation along with diminished cochlear blood flow are essential factors involved in mechanisms of other stress-related hearing loss, such as that associated with noise or ototoxic drug exposure. The emerging view is that both play key roles in ARHL pathogenesis. Therapeutic targeting of excessive free radical formation and cochlear blood flow regulation may be a useful strategy to prevent onset of ARHL. Supporting this idea, micronutrient-based therapies, in particular those combining antioxidants and vasodilators like magnesium (Mg2+), have proven effective in reducing the impact of noise and ototoxic drugs in the inner ear, therefore improving auditory function. In this review, the synergistic effects of combinations of antioxidant free radicals scavengers and cochlear vasodilators will be discussed as a feasible therapeutic approach for the treatment of ARHL.
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影响因子：
3.6
作者：
Ciorba A;Bianchini C;Pelucchi S;Pastore A
通讯作者：
Pastore A
影响因子：
2.8
作者：
Davis, Rickie R.;Kuo, Ming-Wen;Alagramam, Kumar N.
通讯作者：
Alagramam, Kumar N.
DOI：
10.1007/bf00454034
发表时间：
1982-01-01
期刊：
ARCHIVES OF OTO-RHINO-LARYNGOLOGY-ARCHIV FUR OHREN-NASEN-UND KEHLKOPFHEILKUNDE
影响因子：
--
作者：
ISING, H;HANDROCK, M;DOMBROWSKI, M
通讯作者：
DOMBROWSKI, M
DOI：
10.1044/1092-4388(2002/100
发表时间：
2002-12-01
影响因子：
2.6
作者：
Boettcher, FA
通讯作者：
Boettcher, FA
Wistar 大鼠：一种被遗忘的与年龄相关的听力损失模型。
影响因子：
4.8
作者：
Alvarado JC;Fuentes-Santamaría V;Gabaldón-Ull MC;Blanco JL;Juiz JM
通讯作者：
Juiz JM