A population of descending neurons that regulates the flight motor of Drosophila.
A population of descending neurons that regulates the flight motor of Drosophila.
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DOI：
10.1016/j.cub.2022.01.008
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发表时间：
2022-03-14
期刊：
影响因子：
9.2
通讯作者：
Dickinson, Michael H.
中科院分区：
文献类型：
--
作者：
Namiki, Shigehiro;Ros, Ivo G.;Morrow, Carmen;Rowell, William J.;Card, Gwyneth M.;Korff, Wyatt;Dickinson, Michael H.
与许多昆虫一样，果蝇能够在长达几个小时的时间内保持稳定的飞行轨迹。由于空气动力扭矩大致与机翼长度的五次方成正比，因此即使机翼尺寸存在微小的不对称性，也需要在扑动运动中维持微妙的双边差异，以保持稳定的路径。苍蝇甚至可以在失去一半翅膀后直线飞行，这是它们通过对受损和完整翅膀进行非常大的、持续的运动变化来实现的壮举。因此，负责稳定飞行的神经网络必须能够在大动态范围内维持对机翼运动的精细控制。在本文中，我们描述了一种不寻常的下降神经元（DNg02），它直接从大脑的视觉输出区域投射到腹神经索的背飞行神经元。与许多以具有独特形态的单个双侧对存在的下降神经元不同，存在至少 15 个具有几乎相同形状的 DNg02 细胞对的群体。通过光遗传学激活不同数量的 DNg02 细胞，我们证明这些神经元通过群体密码在宽动态范围内调节翅膀的振幅。使用 2 光子功能成像，我们表明 DNg02 细胞在飞行过程中对视觉运动做出响应，这使得它们非常适合连续调节机翼运动学的双边变化。总的来说，我们已经确定了一组关键的 DN，它们可以提供飞行控制所需的灵敏度和动态范围。 Namiki 等人在飞行的苍蝇中使用激活屏幕。识别出在大动态范围内调节翼振幅的下降神经元群体。通过功能成像和不同数量细胞的激活，他们表明该细胞群是飞行回路的核心组成部分，使苍蝇能够操纵和直线飞行。
Like many insect species, Drosophila melanogaster are capable of maintaining a stable flight trajectory for periods lasting up to several hours. Because aerodynamic torque is roughly proportional to the fifth power of wing length, even small asymmetries in wing size require the maintenance of subtle bilateral differences in flapping motion to maintain a stable path. Flies can even fly straight after losing half of a wing, a feat they accomplish via very large, sustained kinematic changes to both the damaged and intact wings. Thus, the neural network responsible for stable flight must be capable of sustaining fine-scaled control over wing motion across a large dynamic range. In this paper, we describe an unusual type of descending neuron (DNg02) that projects directly from visual output regions of the brain to the dorsal flight neuropil of the ventral nerve cord. Unlike many descending neurons, which exist as single bilateral pairs with unique morphology, there is a population of at least 15 DNg02 cell pairs with nearly identical shape. By optogenetically activating different numbers of DNg02 cells, we demonstrate that these neurons regulate wingbeat amplitude over a wide dynamic range via a population code. Using 2-photon functional imaging, we show that DNg02 cells are responsive to visual motion during flight in a manner that would make them well suited to continuously regulate bilateral changes in wing kinematics. Collectively, we have identified a critical set of DNs that provide the sensitivity and dynamic range required for flight control. Using an activation screen in flying flies, Namiki et al. identify a population of descending neurons that regulates wing amplitude over a large dynamic range. Via functional imaging and activation of different numbers of cells, they show that this population is a core component of the flight circuit, allowing the fly to steer and fly straight.
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DOI：
10.1073/pnas.1323529111
发表时间：
2014-04-01
影响因子：
11.1
作者：
Fuller, Sawyer Buckminster;Straw, Andrew D.;Dickinson, Michael H.
通讯作者：
Dickinson, Michael H.
影响因子：
7.7
作者：
Aso Y;Hattori D;Yu Y;Johnston RM;Iyer NA;Ngo TT;Dionne H;Abbott LF;Axel R;Tanimoto H;Rubin GM
通讯作者：
Rubin GM
影响因子：
4.6
作者：
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通讯作者：
Bhandawat, Vikas
影响因子：
2.8
作者：
Budick, Seth A.;Reiser, Michael B.;Dickinson, Michael H.
通讯作者：
Dickinson, Michael H.
影响因子：
2.5
作者：
HENNEMAN, E;SOMJEN, G;CARPENTER, DO
通讯作者：
CARPENTER, DO