Nanoproteomics comes of age.
Nanoproteomics comes of age.
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DOI:
10.1080/14789450.2018.1537787
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发表时间:
2018-11
影响因子:
3.4
通讯作者:
Qian WJ
中科院分区:
文献类型:
--
作者:
Zhu Y;Piehowski PD;Kelly RT;Qian WJ
Nanoproteomics, which is defined as quantitative proteome profiling of small populations of cells (<5000 cells), can reveal critical information related to rare cell populations, hard-to-obtain clinical specimens, and the cellular heterogeneity of pathological tissues. We present a brief review of the recent technological advances in nanoproteomics. These advances include new technologies or approaches covering major areas of proteomics workflow ranging from sample isolation, sample processing, high-resolution separations, to MS instrumentation. We comment on the current state of nanoproteomics and discuss perspectives on both future technological directions and potential enabling applications.
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