Newly identified prions in budding yeast, and their possible functions.

Newly identified prions in budding yeast, and their possible functions.
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DOI:
10.1016/j.semcdb.2011.03.003
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发表时间:
2011-07
影响因子:
7.3
通讯作者:
Li L
Li L
中科院分区:
生物学2区
文献类型:
--
作者:
Crow ET;Li L

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酵母朊病毒是一种非典型的遗传因子,以可遗传的蛋白质构象形式传播。[PSI+]、[URE3]和[PIN+]是芽殖酵母(Saccharomycescerevisiae)中的三种充分研究的朊病毒。在过去的三年中,在酵母中报道了几种其他朊病毒,包括[SWI+]、[OCT+]、[MCA]、[GAR+]、[MOT3+]、[ISP+]和[NSI+]。酵母朊病毒数量的不断增加表明基于蛋白质的遗传可能是一种普遍的生物学现象。本文综述了朊病毒各元件的特性,并讨论了它们在酵母生物学中的潜在功能。
Yeast prions are atypical genetic elements that are transmitted as heritable protein conformations. [PSI+], [URE3], and [PIN+] are three well-studied prions in the budding yeast, Saccharomyces cerevisiae. In the last three years, several additional prions have been reported in yeast, including [SWI+], [OCT+], [MCA], [GAR+], [MOT3+], [ISP+], and [NSI+]. The growing number of yeast prions suggests that protein-based inheritance might be a widespread biological phenomenon. In this review, we summarize the characteristics of each prion element, and discuss their potential functional roles in yeast biology.
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发表时间: 2008-04-01
期刊: NATURE GENETICS
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