Disorderly conduct in gammadelta versus alphabeta T cell lineage commitment.

Disorderly conduct in gammadelta versus alphabeta T cell lineage commitment.
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gammadelta 与 Alphabeta T 细胞谱系定型中的无序行为。

DOI:
10.1016/j.smim.2010.04.003
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发表时间:
2010
影响因子:
7.8
通讯作者:
Kang,Joonsoo
Kang,Joonsoo
中科院分区:
医学2区
文献类型:
--
作者:
Narayan,Kavitha;Kang,Joonsoo

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The mechanism of T cell precursor commitment to the γδ or αβ T cell lineage remains unclear. While TCR signal strength has emerged as a key factor in lineage commitment based on TCR transgenic models, the entire TCR repertoire may not possess the same discriminatory power. A counterbalance to the TCR as the lineage determinant is the pre-existing heterogeneity in gene expression among precursors, which suggests that single precursors are unlikely to respond homogeneously to a given instructive signal.
转录因子 PLZF 指导 NKT 细胞谱系的效应程序。
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