A Stereolithography-Based 3D Printed Hybrid Scaffold for In Situ Cartilage Defect Repair.
A Stereolithography-Based 3D Printed Hybrid Scaffold for In Situ Cartilage Defect Repair.
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DOI：
10.1002/mabi.201700267
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发表时间：
2018-03
影响因子：
4.6
通讯作者：
Bryant SJ
中科院分区：
文献类型：
--
作者：
Aisenbrey EA;Tomaschke A;Kleinjan E;Muralidharan A;Pascual-Garrido C;McLeod RR;Ferguson VL;Bryant SJ
随着时间的推移，关节软骨的损伤会导致损伤周围的组织退化。为了解决这个问题，需要防止变性并促进新组织生长的支架。我们推出了一种新的混合支架，它将基于立体光刻的三维印刷支撑结构与可注射和可光聚合的水凝胶相结合，用于输送细胞来治疗局灶性软骨缺陷。在这项概念验证研究中，我们证明了以下能力：a）用可注射的水凝胶前体溶液填充支撑结构，b）在填充过程中使用可促进新组织沉积的可降解水凝胶掺入软骨细胞，c）当将混合支架原位放置在机械条件下培养的骨软骨塞的局灶性软骨缺损中时，最大限度地减少对周围软骨的损伤 加载中。由于能够独立控制结构和可注射水凝胶的特性，这种混合支架方法有望治疗软骨缺陷。
Damage to articular cartilage can over time cause degeneration to the tissue surrounding the injury. To address this problem, scaffolds that prevent degeneration and promote neotissue growth are needed. We introduce a new hybrid scaffold that combines a stereolithography-based three-dimensional printed support structure with an injectable and photopolymerizable hydrogel for delivering cells to treat focal chondral defects. In this proof of concept study, we demonstrate the ability to a) infill the support structure with an injectable hydrogel precursor solution, b) incorporate cartilage cells during infilling using a degradable hydrogel that promotes neotissue deposition, and c) minimize damage to the surrounding cartilage when the hybrid scaffold is placed in situ in a focal chondral defect in an osteochondral plug that is cultured under mechanical loading. With the ability to independently control the properties of the structure and the injectable hydrogel, this hybrid scaffold approach holds promise for treating chondral defects.
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影响因子：
3.8
作者：
Kinneberg KR;Nelson A;Stender ME;Aziz AH;Mozdzen LC;Harley BA;Bryant SJ;Ferguson VL
通讯作者：
Ferguson VL
影响因子：
2.8
作者：
Lee, Seung-Jae;Kang, Hyun-Wook;Cho, Dong-Woo
通讯作者：
Cho, Dong-Woo
影响因子：
--
作者：
Maldonado M;Nam J
通讯作者：
Nam J
影响因子：
46.9
作者：
Kang, Hyun-Wook;Lee, Sang Jin;Atala, Anthony
通讯作者：
Atala, Anthony
影响因子：
3.8
作者：
Linnenberger, Anna;Bodine, Martha I.;McLeod, Robert R.
通讯作者：
McLeod, Robert R.