Overcoming transport barriers for interstitial-, lymphatic-, and lymph node-targeted drug delivery.
Overcoming transport barriers for interstitial-, lymphatic-, and lymph node-targeted drug delivery.
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DOI：
10.1016/j.coche.2014.11.003
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发表时间：
2015-02-01
影响因子：
6.6
通讯作者：
Schudel A
中科院分区：
文献类型：
--
作者：
Thomas SN;Schudel A
尽管药物制剂改善了循环时间和靶向性，但由于对靶组织的渗透和保留不足而阻碍了疗效。这篇综述强调了限制向结缔组织间质、淋巴管和淋巴结输送的障碍，以及工程药物载体克服这些输送挑战的进展。三维组织生理学是在提供输送到这些组织的材料设计原理的背景下讨论的；特别是间质和淋巴流动以及血液和毛细淋巴管渗透性差异的影响。讨论了为克服这些运输障碍而开发的具有不同特性的材料的关键示例以及进一步开发的潜在领域。
Despite drug formulation improving circulation times and targeting, efficacy is stymied by inadequate penetration into and retention within target tissues. This review highlights the barriers restricting delivery to the connective tissue interstitium, lymphatics, and lymph nodes as well as advances in engineering drug carriers to overcome these delivery challenges. Three-dimensional tissue physiology is discussed in the context of providing material design principles for delivery to these tissues; in particular the influence of interstitial and lymphatic flows as well as differential permeabilities of the blood and lymphatic capillaries. Key examples of materials with different characteristics developed to overcome these transport barriers are discussed as well as potential areas for further development.
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影响因子：
14
作者：
Liu, Rong;Gilmore, Denis M.;Zubris, Kimberly Ann V.;Xu, Xiaoyin;Catalano, Paul J.;Padera, Robert F.;Grinstaff, Mark W.;Colson, Yolonda L.
通讯作者：
Colson, Yolonda L.
影响因子：
46.9
作者：
通讯作者：
--
影响因子：
3.7
作者：
Lin CC;Anseth KS
通讯作者：
Anseth KS
影响因子：
82.9
作者：
Alexandrakis, G;Brown, EB;Jain, RK
通讯作者：
Jain, RK
DOI：
10.1073/pnas.1105200108
发表时间：
2011-09-20
影响因子：
11.1
作者：
Jewell, Christopher M.;Lopez, Sandra C. Bustamante;Irvine, Darrell J.
通讯作者：
Irvine, Darrell J.