Chromosomal macrodomains and associated proteins: implications for DNA organization and replication in gram negative bacteria.
Chromosomal macrodomains and associated proteins: implications for DNA organization and replication in gram negative bacteria.
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DOI：
10.1371/journal.pgen.1002123
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发表时间：
2011-06
期刊：
影响因子：
4.5
通讯作者：
Grainger DC
中科院分区：
文献类型：
--
作者：
Dame RT;Kalmykowa OJ;Grainger DC
大肠杆菌染色体被组织成四个大结构域，其功能和组织尚不清楚。在这篇综述中，我们将重点关注最近被鉴定为具有大结构域特异性dna结合特性的第一批因子的MatP、SeqA和SlmA蛋白。特别是，我们回顾了证据表明，这些因素有助于控制染色体的复制和分离，特别是针对基因组的亚区，并有助于其独特的性质。对包括致病物种在内的多种相关细菌的基因组序列分析表明，SeqA、SlmA和MatP的大结构域特异性分布是保守的，这提示了这些生物中染色体组织的共同原则。这一发现表明，还有其他具有类似特异性的蛋白质尚未被发现。我们讨论了迄今为止确定的蛋白质的作用以及可能用于发现新因素的策略。
The Escherichia coli chromosome is organized into four macrodomains, the function and organisation of which are poorly understood. In this review we focus on the MatP, SeqA, and SlmA proteins that have recently been identified as the first examples of factors with macrodomain-specific DNA-binding properties. In particular, we review the evidence that these factors contribute towards the control of chromosome replication and segregation by specifically targeting subregions of the genome and contributing towards their unique properties. Genome sequence analysis of multiple related bacteria, including pathogenic species, reveals that macrodomain-specific distribution of SeqA, SlmA, and MatP is conserved, suggesting common principles of chromosome organisation in these organisms. This discovery of proteins with macrodomain-specific binding properties hints that there are other proteins with similar specificity yet to be unveiled. We discuss the roles of the proteins identified to date as well as strategies that may be employed to discover new factors.
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