Touch inhibits touch: sanshool-induced paradoxical tingling reveals perceptual interaction between somatosensory submodalities.
Touch inhibits touch: sanshool-induced paradoxical tingling reveals perceptual interaction between somatosensory submodalities.
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DOI：
10.1098/rspb.2020.2914
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发表时间：
2021-01-27
期刊：
影响因子：
--
通讯作者：
Haggard P
中科院分区：
文献类型：
--
作者：
Cataldo A;Hagura N;Hyder Y;Haggard P
人类对触摸的感知是通过多个渠道的输入来调节的。经典理论假设每个通道对每个触觉特征的独立贡献，通道之间很少或没有相互作用。与此观点相反，我们表明来自机械输入通道的两种子模态的输入相互作用以确定触觉感知。颤动范围的振动通道被羟基-α-山椒素异常激活，羟基-α-山椒素是四川辣椒的一种生物活性化合物，它通过化学方式引起类似振动的刺痛感。我们测试了嘴唇上的这种刺痛感是否受到持续机械压力的调节。通过四项实验，我们发现持续的触摸会以特定位置、压力水平和时间依赖性的方式抑制山椒素的刺痛感。其他实验排除了伤害性或情感（C-触觉）通道介导的这种相互作用。这些结果揭示了稳定压力对颤动范围触觉感知通道的新抑制影响，与体感通路内机械感受器输入之间的早期相互作用一致。
Human perception of touch is mediated by inputs from multiple channels. Classical theories postulate independent contributions of each channel to each tactile feature, with little or no interaction between channels. In contrast to this view, we show that inputs from two sub-modalities of mechanical input channels interact to determine tactile perception. The flutter-range vibration channel was activated anomalously using hydroxy-α-sanshool, a bioactive compound of Szechuan pepper, which chemically induces vibration-like tingling sensations. We tested whether this tingling sensation on the lips was modulated by sustained mechanical pressure. Across four experiments, we show that sustained touch inhibits sanshool tingling sensations in a location-specific, pressure-level and time-dependent manner. Additional experiments ruled out the mediation of this interaction by nociceptive or affective (C-tactile) channels. These results reveal novel inhibitory influence from steady pressure onto flutter-range tactile perceptual channels, consistent with early-stage interactions between mechanoreceptor inputs within the somatosensory pathway.
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