Does birth weight affect neonatal body weight, growth, and physiology in an animal model?
Does birth weight affect neonatal body weight, growth, and physiology in an animal model?
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DOI：
10.1371/journal.pone.0246954
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
German RZ
中科院分区：
文献类型：
--
作者：
Adjerid K;Mayerl CJ;Gould FDH;Edmonds CE;Stricklen BM;Bond LE;German RZ
在幼猪模型中，婴儿出生体重影响神经运动和生物力学吞咽性能。早产儿通常出生时体重较低，并患有发育迟缓和神经运动缺陷。这些缺陷包括关键的生活技能，如吞咽和呼吸。目前尚不清楚这些神经运动和生物力学缺陷是低出生体重还是早产造成的。在这项研究中，我们问：早产儿仅仅是低出生体重儿，还是早产儿在体重增加和吞咽行为方面与足月儿不同，独立于出生体重？我们使用一个经过验证的婴儿猪模型来表明，早产儿和足月儿的体重增加是不同的，出生体重并不是早产儿吞咽功能缺陷的有力预测因子。我们发现，早产儿体重增加的速度比足月儿快，变异几乎是足月儿的三倍。此外，我们发现每一只燕子的吸吮次数、吞咽持续时间以及燕子相对于吸吮周期的延迟并不受出生体重的影响。这些结果表明，发育或吞咽缺陷与出生体重降低的任何相关性都可能与早产儿潜在的生理不成熟有关。
Infant birth weight affects neuromotor and biomechanical swallowing performance in infant pig models. Preterm infants are generally born low birth weight and suffer from delayed development and neuromotor deficits. These deficits include critical life skills such as swallowing and breathing. It is unclear whether these neuromotor and biomechanical deficits are a result of low birth weight or preterm birth. In this study we ask: are preterm infants simply low birth weight infants or do preterm infants differ from term infants in weight gain and swallowing behaviors independent of birth weight? We use a validated infant pig model to show that preterm and term infants gain weight differently and that birth weight is not a strong predictor of functional deficits in preterm infant swallowing. We found that preterm infants gained weight at a faster rate than term infants and with nearly three times the variation. Additionally, we found that the number of sucks per swallow, swallow duration, and the delay of the swallows relative to the suck cycles were not impacted by birth weight. These results suggest that any correlation of developmental or swallowing deficits with reduced birth weight are likely linked to underlying physiological immaturity of the preterm infant.
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影响因子：
2.4
作者：
Mayerl，Christopher J.;Catchpole，Emily A.;German，Rebecca Z.
通讯作者：
German，Rebecca Z.
影响因子：
3
作者：
Abitbol, CL;Bauer, CR;Zilleruelo, G
通讯作者：
Zilleruelo, G
影响因子：
2.6
作者：
Ballester A;Gould F;Bond L;Stricklen B;Ohlemacher J;Gross A;DeLozier K;Buddington R;Buddington K;Danos N;German R
通讯作者：
German R
影响因子：
3.7
作者：
Eiby, Yvonne A.;Wright, Layne L.;Lingwood, Barbara E.
通讯作者：
Lingwood, Barbara E.
DOI：
10.1093/iob/obaa028
发表时间：
2020
期刊：
Integrative organismal biology (Oxford, England)
影响因子：
--
作者：
Edmonds CE;Catchpole EA;Gould FDH;Bond LE;Stricklen BM;German RZ;Mayerl CJ
通讯作者：
Mayerl CJ