Maturation of the Coordination Between Respiration and Deglutition with and Without Recurrent Laryngeal Nerve Lesion in an Animal Model.
Maturation of the Coordination Between Respiration and Deglutition with and Without Recurrent Laryngeal Nerve Lesion in an Animal Model.
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DOI：
10.1007/s00455-018-9881-z
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发表时间：
2018-10
期刊：
影响因子：
2.6
通讯作者：
German R
中科院分区：
文献类型：
--
作者：
Ballester A;Gould F;Bond L;Stricklen B;Ohlemacher J;Gross A;DeLozier K;Buddington R;Buddington K;Danos N;German R
呼吸周期中吞咽发生的时间对于安全吞咽至关重要，并随婴儿发育而变化。喉返神经接收来自喉的感觉信息并供应喉内肌，喉返神经损伤的婴儿会发生显著的吞咽困难。使用我们经过验证的幼猪模型，我们确定了这种神经损伤与出生后发育期间呼吸和吞咽之间的协调之间的相互作用。我们记录了23个婴儿猪在两个年龄（新生儿和老年人，断奶前）喂养的牛奶钡使用同步高速视频荧光镜检查和胸部运动的测量。使用一个完整的线性模型，我们测试了随着成熟的变化，以及这些变化在对照组和病变组中是否相同。我们发现（1）吞咽和呼吸协调的时间随着成熟而改变;（2）喉返神经损伤对协调时间没有总体影响，但（3）喉返神经损伤发生更大幅度的成熟变化。我们还确定，未进行手术干预的动物与进行标记放置手术和神经损伤假手术的动物没有差异。呼吸和吞咽之间的协调在正常的完整个体中发生变化，以在断奶前提供增加的气道保护。此外，在RLN病变的动物中，成熟过程具有更大的影响。最后，这些结果表明，这两个功能的脑干感觉运动相互作用的高水平。
The timing of the occurrence of a swallow in a respiratory cycle is critical for safe swallowing, and changes with infant development. Infants with damage to the recurrent laryngeal nerve, which receives sensory information from the larynx and supplies the intrinsic muscles of the larynx, experience a significant incidence of dysphagia. Using our validated infant pig model, ewe determined the interaction between this nerve damage and the coordination between respiration and swallowing during postnatal development. We recorded 23 infant pigs at two ages (neonatal and older, pre-weaning) feeding on milk with barium using simultaneous highspeed videofluroscopy and measurements of thoracic movement. With a complete linear model, we tested for changes with maturation, and whether these changes are the same in control and lesioned individuals. We found (1) the timing of swallowing and respiration coordination changes with maturation; (2) no overall effect of RLN lesion on the timing of coordination, but (3) a greater magnitude of maturational change occurs with RLN injury. We also determined that animals with no surgical intervention did not differ from animals that had surgery for marker placement and a sham procedure for nerve lesion. The coordination between respiration and swallowing changes in normal, intact individuals to provide increased airway protection prior to weaning. Further, in animals with an RLN lesion, the maturation process has a larger effect. Finally, these results suggest a high level of brainstem sensorimotor interactions with respect to these two functions.
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影响因子：
2.6
作者：
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作者：
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通讯作者：
German, Rebecca Z.
影响因子：
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通讯作者：
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