Combined Associations of Serum Ferritin and Body Size Phenotypes With Cardiovascular Risk Profiles: A Chinese Population-Based Study.
Combined Associations of Serum Ferritin and Body Size Phenotypes With Cardiovascular Risk Profiles: A Chinese Population-Based Study.
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血清铁蛋白和体型表型与心血管风险状况的综合关联：一项基于中国人群的研究
DOI：
10.3389/fpubh.2021.550011
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发表时间：
2021
影响因子：
5.2
通讯作者：
Yuan G
中科院分区：
文献类型：
--
作者：
Zhou B;Liu S;Yuan G
背景：血清铁蛋白 (SF) 与一种或多种与心血管疾病 (CVD) 风险增加相关的代谢综合征特征相关。本研究探讨了基于代谢状态和体重指数 (BMI) 类别的不同体型表型之间 SF 和 CVD 危险因素之间的关联。方法：对来自中国健康与营养调查的 7,549 名中国成年人进行了一项横断面研究。参与者没有表现出急性炎症，体重也没有不足，并根据他们的代谢状态和体重指数类别进行分层。代谢危险状态被定义为具有成人治疗组-III代谢综合征定义的两个或多个标准，不包括腰围。结果：与没有高 SF 的个体相比，有高 SF 的受试者在代谢风险正常体重 (MANW) 和代谢风险超重/肥胖 (MAO) 组中患糖尿病的风险增加。多变量调整优势比 (OR) 分别为 1.52 [95% 置信区间 (Cls)：1.02, 2.28] 和 1.63 (95% Cls：1.27, 2.09)。代谢健康正常体重 (MHNW)、代谢健康超重/肥胖 (MHO)、MANW 和 MAO 表型中高 SF 引起的高尿酸血症的调整 OR 分别为 1.78（95% Cls：1.26、2.53）、1.42（95% Cls：1.03、1.95）、1.66（95% Cls：分别为 1.17、2.36）和 1.42（95% Cls：1.17、1.73）。同样，在所有表型中都观察到高 SF 与甘油三酯、非高密度脂蛋白胆固醇和载脂蛋白 B100 呈正相关。在代谢风险较高的参与者中，无论其 BMI 类别如何，均未观察到高 SF 与升高的低密度脂蛋白胆固醇之间存在关联。然而，高 SF 导致低密度脂蛋白胆固醇升高的 OR 在 MHNW 组中为 1.64（95% Cls：1.29、2.08），在 MHO 组中为 1.52（95% Cls：1.22、1.91），显着。这项研究表明，对于除低密度脂蛋白胆固醇之外的所有不利 CVD 危险因素，具有高 SF 的 MAO 组的 OR 最高（所有 p < 0.001）。结论：高 SF 与 CVD 危险因素（包括糖尿病、血脂异常和高尿酸血症）患病率的关联在不同体型表型的个体中存在差异。在 MAO 组中，SF 水平高的受试者比 SF 水平低的受试者表现出更差的 CVD 风险状况。
Background: Serum ferritin (SF) has been correlated with one or more metabolic syndrome features associated with an increased risk for cardiovascular disease (CVD). This study explored the associations between SF and CVD risk factors among different body size phenotypes that were based on metabolic status and body mass index (BMI) categories. Methods: A cross-sectional study was performed using a cohort of 7,549 Chinese adults from the China Health and Nutrition Survey. Participants did not exhibit acute inflammation, were not underweight and were stratified based on their metabolic status and BMI categories. The metabolically at-risk status was defined as having two or more criteria of the Adult Treatment Panel-III metabolic syndrome definition, excluding waist circumference. Results: Compared with individuals without high SF, subjects with high SF had an increased risk of diabetes in the metabolically at-risk normal-weight (MANW) and metabolically at-risk overweight/obesity (MAO) groups. The multivariate-adjusted odds ratios (ORs) were 1.52 [95% confidence interval (Cls): 1.02, 2.28] and 1.63 (95% Cls: 1.27, 2.09), respectively. Adjusted ORs for hyperuricemia from high SF in metabolically healthy normal-weight (MHNW), metabolically healthy overweight/obesity (MHO), MANW, and MAO phenotypes were 1.78 (95% Cls: 1.26, 2.53), 1.42 (95% Cls: 1.03, 1.95), 1.66 (95% Cls: 1.17, 2.36), and 1.42 (95% Cls: 1.17, 1.73), respectively. Similarly, positive correlations of high SF with triglycerides, non-high-density lipoprotein cholesterol, and apolipoprotein B100 were observed in all phenotypes. No association between high SF and elevated low-density lipoprotein cholesterol were observed among participants who were metabolically at-risk, regardless of their BMI categories. However, the ORs for elevated low-density lipoprotein cholesterol from high SF were 1.64 (95% Cls: 1.29, 2.08) in the MHNW group and 1.52 (95% Cls:1.22, 1.91) in the MHO group, significantly. This study demonstrated that the highest ORs were in MAO with a high SF group for all unfavorable CVD risk factors except low-density lipoprotein cholesterol (all p < 0.001). Conclusions: The associations of high SF with the prevalence of CVD risk factors, including diabetes, dyslipidemia, and hyperuricemia, vary in individuals among different body size phenotypes. In the MAO group, subjects with high SF levels exhibited worse CVD risk profiles than individuals without high SF.
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影响因子：
5.5
作者：
Martelin, E;Lapatto, R;Raivio, KO
通讯作者：
Raivio, KO
影响因子：
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影响因子：
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American Diabetes Association
通讯作者：
American Diabetes Association