Follow-up study on serum cholesterol profiles and potential sequelae in recovered COVID-19 patients.
Follow-up study on serum cholesterol profiles and potential sequelae in recovered COVID-19 patients.
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DOI：
10.1186/s12879-021-05984-1
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发表时间：
2021-03-24
影响因子：
3.7
通讯作者：
Wang H
中科院分区：
文献类型：
--
作者：
Li G;Du L;Cao X;Wei X;Jiang Y;Lin Y;Nguyen V;Tan W;Wang H
COVID-19患者会出现低血脂症。然而，目前尚不清楚血脂水平是否有所改善，在恢复的患者中是否存在潜在的sequlae。在这项随访研究中，我们评估了恢复患者的血清肌酐和各种病理生理学实验室值。在2020年6月15日至9月3日期间进行了一项3-6个月的随访研究，以检查107名出院的COVID-19患者（轻度= 59;重度/危重= 48;入院时诊断）的血清实验室值水平。61例患者进行了再次胸部CT扫描。采用Wilcoxon符号秩检验分析入院和随访时实验室检查值的变化。重型/危重病例随访时LDL-c和HDL-c水平显著高于入院时（p < 0.05）。轻度病例随访时LDL-c水平显著高于入院时（p < 0.05）。随访时患者凝血功能和肝功能值较入院时显著改善（p < 0.05）。在患者恢复期间，HDL-c的增加与白色血细胞数量的增加显著相关（p < 0.001）。排除服用中药或降胆固醇药物的受试者，重型/危重病例随访时LDL-c和HDL-c水平较入院时显著升高（p < 0.05）。在72%（44/61）的随访患者的CT图像中观察到残留病变。在3-6个月随访时，观察到恢复患者的LDL-c、HDL-c、肝功能改善和肺部病变不完全消退，表明可能需要长期恢复过程，并且某些患者可能会出现后遗症，如肺纤维化。
COVID-19 patients develop hypolipidemia. However, it is unknown whether lipid levels have improved and there are potential sequlae in recovered patients. In this follow-up study, we evaluated serum lipidemia and various physiopathological laboratory values in recovered patients. A 3–6 month follow-up study was performed between June 15 and September 3, 2020, to examine serum levels of laboratory values in 107 discharged COVID-19 patients (mild = 59; severe/critical = 48; diagnoses on admission). Sixty-one patients had a revisit chest CT scan. A Wilcoxon signed-rank test was used to analyze changes in laboratory values at admission and follow-up. LDL-c and HDL-c levels were significantly higher at follow-up than at admission in severe/critical cases (p < 0.05). LDL-c levels were significantly higher at follow-up than at admission in mild cases (p < 0.05). Coagulation and liver functional values were significantly improved at follow-up than at admission for patients (p < 0.05). Increases in HDL-c significantly correlated with increases in numbers of white blood cells (p < 0.001) during patients’ recovery. With exclusion of the subjects taking traditional Chinese medicines or cholesterol-lowering drugs, LDL-c and HDL-c levels were significantly increased at follow-up than at admission in severe/critical cases (p < 0.05). Residue lesions were observed in CT images in 72% (44 of 61) of follow-up patients. Improvements of LDL-c, HDL-c, liver functions, and incomplete resolution of lung lesions were observed at 3–6 month follow-up for recovered patients, indicating that a long-term recovery process could be required and the development of sequelae such as pulmonary fibrosis could be expected in some patients.
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肺功能和肺部射线照相变化的后续研究在恢复严重的急性呼吸道综合征患者时。
影响因子：
9.6
作者：
Xie L;Liu Y;Xiao Y;Tian Q;Fan B;Zhao H;Chen W
通讯作者：
Chen W
DOI：
10.4103/ijri.ijri_469_16
发表时间：
2017-07
期刊：
The Indian journal of radiology & imaging
影响因子：
--
作者：
Das KM;Lee EY;Singh R;Enani MA;Al Dossari K;Van Gorkom K;Larsson SG;Langer RD
通讯作者：
Langer RD
影响因子：
5.4
作者：
Wan, Yushun;Shang, Jian;Li, Fang
通讯作者：
Li, Fang
影响因子：
7.5
作者：
Klok, F. A.;Kruip, M. J. H. A.;Endeman, H.
通讯作者：
Endeman, H.
严重急性呼吸综合症对幸存者队列中肺功能，运动能力和生活质量的1年影响。
影响因子：
9.6
作者：
Hui DS;Wong KT;Ko FW;Tam LS;Chan DP;Woo J;Sung JJ
通讯作者：
Sung JJ