Employing genetic markers to improve diagnosis of thyroid tumor fine needle biopsy.

Employing genetic markers to improve diagnosis of thyroid tumor fine needle biopsy.
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DOI:
10.2174/138920211798120781
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发表时间:
2011-12
期刊:
影响因子:
2.6
通讯作者:
Cerutti JM
Cerutti JM
中科院分区:
生物学4区
文献类型:
--
作者:
Cerutti JM

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细针穿刺术(FNA)是最广泛使用和最具成本效益的术前检查,用于甲状腺结节的初步评估,尽管它对几种类型的肿瘤的诊断准确性有限。患者通常会收到不确定细胞学的细胞学报告,并被转介到手术以获得更准确的诊断。一种改进的检测方法将有助于医生迅速将治疗重点放在真正的恶性肿瘤上,避免对良性肿瘤进行一些不必要的治疗。本文将讨论目前可能提高甲状腺结节诊断的分子标志物。
Fine-Needle Aspiration (FNA) is the most widely used and cost-effective preoperative test for the initial evaluation of a thyroid nodule, although it has limited diagnostic accuracy for several types of tumors. Patients will often receive cytological report of indeterminate cytology and are referred to surgery for a more accurate diagnosis. An improved test would help physicians rapidly focus treatment on true malignancies and avoid some unnecessary treatment of benign tumors. This review will discuss current molecular markers that may improve thyroid nodule diagnosis.
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