The interaction of childhood height and childhood BMI in the prediction of young adult BMI.
The interaction of childhood height and childhood BMI in the prediction of young adult BMI.
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DOI：
10.1038/oby.2008.359
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发表时间：
2008-10
期刊：
影响因子：
--
通讯作者：
Himes JH
中科院分区：
文献类型：
--
作者：
Stovitz SD;Pereira MA;Vazquez G;Lytle LA;Himes JH
本研究的目的是检验儿童身高和儿童BMI在预测青年BMI中的相互作用。本研究的2802名受试者来自儿童和青少年心血管健康试验（CATCH）。在三年级（平均年龄8.7岁）和十二年级（平均年龄18.3岁）分别测量受试者的身高和体重。采用以成人BMI为因变量的混合线性回归模型评估身高（cm）与BMI （kg/m2）之间的相关性和相互作用。我们发现儿童期身高和儿童期BMI在预测成人BMI方面存在显著的交互作用（P < 0.0001）。美国疾病控制与预防中心（CDC）参考五分位数的分层显示，儿童身高与成人BMI呈正相关，仅存在于儿童BMI最高五分位数的受试者中，其中身高最低五分位数的预测成人BMI为27.5(95%可信区间= 26.4-28.6)，身高最高五分位数的预测成人BMI为30.2（95%可信区间= 29.7-30.6）。在身体质量指数高的儿童中，身高较高的儿童成年后的身体质量指数明显高于较矮的儿童。这种模式似乎主要是由于儿童身高和儿童体重指数呈正相关。临床医生应该认识到所有高BMI儿童在成年早期体重超标的风险，并特别注意那些身材高大的儿童，因为他们童年时期的身高并不能保护他们免受随后体重增加和BMI升高的影响。
The purpose of this study was to examine the interaction of childhood height and childhood BMI in the prediction of young adult BMI. The 2,802 subjects in this study were from the Child and Adolescent Trial for Cardiovascular Health (CATCH). The subjects' heights and weights were measured in 3rd grade (mean age 8.7 years) and again in 12th grade (mean age 18.3 years). The associations and interactions between height (cm) and BMI (kg/m2) were assessed using mixed linear regression models with adult BMI as the dependent variable. We found a significant interaction between childhood height and childhood BMI in the prediction of adult BMI (P < 0.0001). Stratification by Centers for Disease Control and Prevention (CDC) reference quintiles revealed that a positive association between childhood height and adult BMI existed only for those subjects in the top quintile of childhood BMI, within whom predicted adult BMI ranged from 27.5 (95% confidence interval = 26.4-28.6) for those in the shortest height quintile to 30.2 (95% confidence interval = 29.7-30.6) for those in the highest height quintile. Among children with high BMI levels, those who were taller, as compared to those who were shorter, had significantly higher young adult BMI levels. This pattern seems primarily due to the positive association of childhood height and childhood BMI. Clinicians should recognize the risk of excess body weight in young adulthood for all children who have a high BMI, and pay special attention to those who are tall, because their childhood height will not protect them from subsequent weight gain and elevated BMI.
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