microRNAs in Parkinson's Disease: From Pathogenesis to Novel Diagnostic and Therapeutic Approaches.
microRNAs in Parkinson's Disease: From Pathogenesis to Novel Diagnostic and Therapeutic Approaches.
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DOI：
10.3390/ijms18122698
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发表时间：
2017-12-13
影响因子：
5.6
通讯作者：
Iraci N
中科院分区：
文献类型：
--
作者：
Leggio L;Vivarelli S;L'Episcopo F;Tirolo C;Caniglia S;Testa N;Marchetti B;Iraci N
帕金森病（PD）是最常见的中枢神经系统（CNS）运动障碍和第二常见的神经退行性疾病。PD的特征在于中脑内黑质丘脑部（SNpc）中多巴胺能（DA能）神经元的进行性损失、路易体和神经突中α-突触核蛋白（α-SYN）的积累以及过度的神经炎症。神经变性过程通常在临床症状出现之前开始几十年。因此，只有当大多数相关DA能神经元已经死亡时才能实现诊断，因此，现有的治疗充其量只能是姑息性的。这种毁灭性疾病的原因和机制尚不明确，但遗传易感性和环境因素之间的复杂相互作用被认为是PD病因学的主要贡献者。除了经典基因突变在PD中的作用外，调节基因表达的调控元件的重要性也越来越被认识到。一个例子是microRNA（miRNAs）在CNS内不同神经元群体的发育和稳态中发挥的关键作用，特别是在PD的背景下。最近的报道表明，不同的miRNA参与PD基因的调控，而分析方法揭示了某些miRNA丰度的变化可能与疾病的发作或进展有关。在这篇综述中，我们提供了一个概述最近发现的参与PD病因学的miRNA，特别关注其作为PD生物标志物的潜在相关性，以及它们在PD靶向治疗中的可能用途。
Parkinson’s disease (PD) is the most prevalent central nervous system (CNS) movement disorder and the second most common neurodegenerative disease overall. PD is characterized by the progressive loss of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNpc) within the midbrain, accumulation of alpha-synuclein (α-SYN) in Lewy bodies and neurites and excessive neuroinflammation. The neurodegenerative processes typically begin decades before the appearance of clinical symptoms. Therefore, the diagnosis is achievable only when the majority of the relevant DAergic neurons have already died and for that reason available treatments are only palliative at best. The causes and mechanism(s) of this devastating disease are ill-defined but complex interactions between genetic susceptibility and environmental factors are considered major contributors to the etiology of PD. In addition to the role of classical gene mutations in PD, the importance of regulatory elements modulating gene expression has been increasingly recognized. One example is the critical role played by microRNAs (miRNAs) in the development and homeostasis of distinct populations of neurons within the CNS and, in particular, in the context of PD. Recent reports demonstrate how distinct miRNAs are involved in the regulation of PD genes, whereas profiling approaches are unveiling variations in the abundance of certain miRNAs possibly relevant either to the onset or to the progression of the disease. In this review, we provide an overview of the miRNAs recently found to be implicated in PD etiology, with particular focus on their potential relevance as PD biomarkers, as well as their possible use in PD targeted therapy.
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影响因子：
46.9
作者：
Alvarez-Erviti, Lydia;Seow, Yiqi;Wood, Matthew J. A.
通讯作者：
Wood, Matthew J. A.
DOI：
10.1523/jneurosci.0558-12.2012
发表时间：
2012-06-27
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Åkerblom M;Sachdeva R;Barde I;Verp S;Gentner B;Trono D;Jakobsson J
通讯作者：
Jakobsson J
影响因子：
23.9
作者：
Chen Y;Xiong M;Dong Y;Haberman A;Cao J;Liu H;Zhou W;Zhang SC
通讯作者：
Zhang SC
影响因子：
2.9
作者：
Briggs CE;Wang Y;Kong B;Woo TU;Iyer LK;Sonntag KC
通讯作者：
Sonntag KC
影响因子：
4.1
作者：
Alieva, Anelya Kh.;Filatova, Elena V.;Slominsky, Petr A.
通讯作者：
Slominsky, Petr A.