The Role of Müller Cells in Diabetic Macular Edema.

The Role of Müller Cells in Diabetic Macular Edema.
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Müller细胞在糖尿病黄斑水肿中的作用。

DOI:
10.1167/iovs.64.10.8
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发表时间:
2023-07-03
影响因子:
4.4
通讯作者:
--
中科院分区:
医学2区
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--
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糖尿病黄斑水肿(DME)是糖尿病视网膜病变的常见并发症,也是糖尿病患者视力丧失的主要原因。高血糖引起的代谢紊乱、炎症等多种因素参与了DME的发生发展,但具体机制尚不清楚。Müler细胞是眼底特有的一种大胶质细胞,分布于视网膜各处,在视网膜内稳态中起着独特的作用。本文综述了Müler细胞在DME病理过程中的作用,以及通过基因治疗靶向Müler细胞治疗DME的研究进展。
Diabetic macular edema (DME) is a common complication of diabetic retinopathy and is the leading cause of vision loss in diabetic patients. Various factors, such as metabolic disorders and inflammation caused by hyperglycemia, are involved in the occurrence and development of DME, but the specific mechanism is still unclear. Müller cells are a type of macroglial cell unique to the fundus, distributed throughout the retina, and they play a unique role in retinal homeostasis. This article reviews the role of Müller cells in the pathological process of DME and the research progress in the treatment of DME by targeting Müller cells through gene therapy.
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