Propagating patterns of intrinsic activity along macroscale gradients coordinate functional connections across the whole brain.
Propagating patterns of intrinsic activity along macroscale gradients coordinate functional connections across the whole brain.
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DOI：
10.1016/j.neuroimage.2021.117827
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发表时间：
2021-05-01
期刊：
影响因子：
5.7
通讯作者：
Keilholz, Shella
中科院分区：
文献类型：
--
作者：
Yousefi, Behnaz;Keilholz, Shella
通过静息态功能磁共振成像 (rsfMRI) 和功能连接观察到的人脑的内在活动表现出宏观空间组织，例如功能网络和梯度。动态分析技术表明，功能连通性只是具有不同空间和时间特征的时变模式的总结。更好地理解这些模式可能有助于深入了解大脑内在活动的各个方面，而这些方面无法通过功能连接或从中衍生的空间图来推断，例如功能网络和梯度。在这里，我们描述了整个大脑协调活动的三种时空模式，这些模式是通过对 rsfMRI 时间序列的类似~20秒长的片段进行平均而获得的。在每一种模式中，活动沿着特定的宏观功能梯度传播，同时穿过大脑皮层和大多数其他大脑区域。在某些区域，如丘脑，传播表明了先前未描述的梯度。跨区域的协调活动与已知的基于区域的连接一致，并且区域之间高峰活动时间的细微差别表明了合理的驱动机制。当这些模式从 rsfMRI 时间序列回归时，功能网络内部尤其是功能网络之间的相关性显着减弱，这定量证明了它们在功能连接中的重要作用。综上所述，我们的结果表明，沿着宏观梯度传播内在活动的一些重复模式会产生并协调整个大脑的功能连接。
The intrinsic activity of the human brain, observed with resting-state fMRI (rsfMRI) and functional connectivity, exhibits macroscale spatial organization such as functional networks and gradients. Dynamic analysis techniques have shown that functional connectivity is a mere summary of time-varying patterns with distinct spatial and temporal characteristics. A better understanding of these patterns might provide insight into aspects of the brain’s intrinsic activity that cannot be inferred by functional connectivity or the spatial maps derived from it,such as functional networks and gradients. Here, we describe three spatiotemporal patterns of coordinated activity across the whole brain obtained by averaging similar ∼20-second-long segments of rsfMRI timeseries. In each of these patterns, activity propagates along a particular macroscale functional gradient, simultaneously across the cerebral cortex and in most other brain regions. In some regions, like the thalamus, the propagation suggests previously-undescribed gradients. The coordinated activity across areas is consistent with known tract-based connections, and nuanced differences in the timing of peak activity between regions point to plausible driving mechanisms. The magnitude of correlation within and particularly between functional networks is remarkably diminished when these patterns are regressed from the rsfMRI timeseries, a quantitative demonstration of their significant role in functional connectivity. Taken together, our results suggest that a few recurring patterns of propagating intrinsic activity along macroscale gradients give rise to and coordinate functional connections across the whole brain.
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影响因子：
5.3
作者：
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通讯作者：
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影响因子：
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作者：
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Keilholz, Shella
影响因子：
3.7
作者：
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通讯作者：
Calhoun, Vince D.
影响因子：
5.7
作者：
Hutchison RM;Womelsdorf T;Allen EA;Bandettini PA;Calhoun VD;Corbetta M;Della Penna S;Duyn JH;Glover GH;Gonzalez-Castillo J;Handwerker DA;Keilholz S;Kiviniemi V;Leopold DA;de Pasquale F;Sporns O;Walter M;Chang C
通讯作者：
Chang C
DOI：
10.1073/pnas.1803667115
发表时间：
2018-10-02
影响因子：
11.1
作者：
Vos de Wael R;Larivière S;Caldairou B;Hong SJ;Margulies DS;Jefferies E;Bernasconi A;Smallwood J;Bernasconi N;Bernhardt BC
通讯作者：
Bernhardt BC