Anatomical and microstructural determinants of hippocampal subfield functional connectome embedding.
Anatomical and microstructural determinants of hippocampal subfield functional connectome embedding.
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DOI：
10.1073/pnas.1803667115
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发表时间：
2018-10-02
影响因子：
11.1
通讯作者：
Bernhardt BC
中科院分区：
文献类型：
--
作者：
Vos de Wael R;Larivière S;Caldairou B;Hong SJ;Margulies DS;Jefferies E;Bernasconi A;Smallwood J;Bernasconi N;Bernhardt BC
尽管在研究海马电路的结构和功能方面，死后细胞结构分析和动物电生理学取得了进展，但复杂的解剖学挑战阻碍了对活体人类亚结构组织的详细了解。通过整合高分辨率的结构和休息状态的功能神经成像，我们证明了两个主轴的亚结构组织在人类海马：一个尊重其长轴和第二个海马内折叠的模式，并显着相关的皮质内的微观结构。鉴于海马对认知、情感和疾病的重要性，我们的研究结果提供了一个与认知神经科学、临床神经影像学和网络神经科学相关的整合海马坐标系统。海马在认知和情感中起着关键作用，并作为动物结构/功能研究的模型系统。到目前为止，其复杂的解剖结构对针对其在人类中的亚结构组织的研究提出了挑战。最先进的MRI提供了分辨率和多功能性来识别海马子场，评估其微观结构，并研究其在体内连接的拓扑学原理。我们开发了一种方法来展开人类海马，并在一个大型健康成年人队列中检查内在功能连接的空间变化。除了绘制各分领域之间的共同和独特联系之外，我们还确定了次区域连通性过渡的两个主要轴心。前/后梯度遵循长轴标志和基于任务的功能性MRI的荟萃分析结果，而内侧/外侧梯度遵循海马内折并与皮质髓鞘的代理相关。结果是一致的，在一个独立的样本和高度稳定的休息状态扫描。我们的研究结果提供了强有力的证据，长轴专业化在休息的人类海马，并提出了一个有趣的相互作用之间的连接和微观结构。
Despite the progress made by postmortem cytoarchitectonic analyses and animal electrophysiology in studying the structure and function of the hippocampal circuitry, complex anatomical challenges have prevented a detailed understanding of its substructural organization in living humans. By integrating high-resolution structural and resting-state functional neuroimaging, we demonstrate two main axes of substructural organization in the human hippocampus: one that respects its long axis and a second that follows patterns of hippocampal infolding and significantly correlates with an intracortical microstructure. Given the importance of the hippocampus for cognition, affect, and disease, our results provide an integrated hippocampal coordinate system that is relevant to cognitive neuroscience, clinical neuroimaging, and network neuroscience. The hippocampus plays key roles in cognition and affect and serves as a model system for structure/function studies in animals. So far, its complex anatomy has challenged investigations targeting its substructural organization in humans. State-of-the-art MRI offers the resolution and versatility to identify hippocampal subfields, assess its microstructure, and study topographical principles of its connectivity in vivo. We developed an approach to unfold the human hippocampus and examine spatial variations of intrinsic functional connectivity in a large cohort of healthy adults. In addition to mapping common and unique connections across subfields, we identified two main axes of subregional connectivity transitions. An anterior/posterior gradient followed long-axis landmarks and metaanalytical findings from task-based functional MRI, while a medial/lateral gradient followed hippocampal infolding and correlated with proxies of cortical myelin. Findings were consistent in an independent sample and highly stable across resting-state scans. Our results provide robust evidence for long-axis specialization in the resting human hippocampus and suggest an intriguing interplay between connectivity and microstructure.
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DOI：
10.1523/jneurosci.2180-11.2011
发表时间：
2011-08-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Glasser MF;Van Essen DC
通讯作者：
Van Essen DC
DOI：
10.1073/pnas.1608282113
发表时间：
2016-11-01
影响因子：
11.1
作者：
Margulies, Daniel S.;Ghosh, Satrajit S.;Smallwood, Jonathan
通讯作者：
Smallwood, Jonathan
DOI：
10.1016/j.ijdevneu.2010.03.004
发表时间：
2010-08-01
影响因子：
1.8
作者：
Abraham, Hajnalka;Vincze, Andras;Seress, Laszlo
通讯作者：
Seress, Laszlo
影响因子：
5.3
作者：
Berron, David;Schuetze, Hartmut;Duezel, Emrah
通讯作者：
Duezel, Emrah
影响因子：
4.8
作者：
de Flores, Robin;Mutlu, Justine;Chetelat, Gael
通讯作者：
Chetelat, Gael