Establishing aversive, but not safe, taste memories requires lateralized pontine-cortical connections.
Establishing aversive, but not safe, taste memories requires lateralized pontine-cortical connections.
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DOI：
10.1016/j.bbr.2008.09.030
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发表时间：
2009-02-11
影响因子：
2.7
通讯作者：
Bernstein IL
中科院分区：
文献类型：
--
作者：
Clark EW;Bernstein IL
双侧脑桥臂旁核（PBN）的病变会显著破坏厌恶和安全的味觉记忆加工。为了确定这些病变如何影响前脑神经元激活的模式，将病变与条件性味觉厌恶（CTA）训练后岛叶皮质（IC）和杏仁核中cFos样免疫反应性（FLI）的评估相结合。在PBN病变后，杏仁核和IC中的FLI增加（通常在新的（与熟悉的）CS-US配对后观察到）被消除。这表明PBN病变阻止了关键CS和US信息传输到前脑区域，以处理厌恶和安全的味觉记忆。PBN和IC的单侧不对称病变阻断了CTA采集以及新型CS-US配对后杏仁核中FLI的正常模式，当单侧病变局限于单个半球时未观察到这种效应。交叉断开实验提供了令人信服的证据，PBN和IC之间的功能相互作用是CTA采集所必需的，但不是安全的味觉记忆形成和检索。不同类型的病变对安全和厌恶的味觉记忆的影响之间的分离支持新出现的证据表明，这两种类型的味觉学习的神经基础不同。
Aversive and safe taste memory processing are dramatically disrupted by bilateral lesions of the pontine parabrachial nucleus (PBN). To determine how such lesions affect patterns of neuronal activation in forebrain, lesions were combined with assessment of cFos-like immunoreactivity (FLI) in insular cortex (IC) and amygdala after conditioned taste aversion (CTA) training. Increases in FLI in amygdala and IC, which are normally seen following novel (versus familiar) CS-US pairing, were eliminated after PBN lesions. This suggests that PBN lesions prevent transmission of critical CS and US information to forebrain regions for the processing of both aversive and safe taste memories. Unilateral asymmetrical lesions of PBN and IC blocked CTA acquisition as well as normal patterns of FLI in amygdala after novel CS-US pairing, an effect not seen when unilateral lesions were confined to a single hemisphere. The crossed-disconnection experiments provide compelling evidence that functional interactions between PBN and IC are required for CTA acquisition, but not for safe taste memory formation and retrieval. The dissociation between effects of the different types of lesions on safe and aversive taste memories supports emerging evidence that the neural underpinnings of the two types of taste learning differ.
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影响因子：
2.5
作者：
GALLO, M;BURES, J
通讯作者：
BURES, J
DOI：
10.1037/h0035958
发表时间：
1974-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
KALAT, JW
通讯作者：
KALAT, JW
影响因子：
3.8
作者：
Reilly, S;Trifunovic, R
通讯作者：
Trifunovic, R
影响因子：
2.7
作者：
Wilkins, EE;Bernstein, IL
通讯作者：
Bernstein, IL
影响因子：
3.6
作者：
Cubero, I;Lopez, M;Puerto, A
通讯作者：
Puerto, A