Feedback determines the structure of correlated variability in primary visual cortex.

Feedback determines the structure of correlated variability in primary visual cortex.
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DOI:
10.1038/s41593-018-0089-1
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发表时间:
2018-04
影响因子:
25
通讯作者:
Cumming BG
Cumming BG
中科院分区:
医学1区
文献类型:
--
作者:
Bondy AG;Haefner RM;Cumming BG

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感觉神经元的可变反应往往是弱相关的(尖峰计数相关,rsc)。这被广泛认为反映了共享传入神经中的噪音,在这种情况下,rsc会限制感觉编码的可靠性。然而,这也可能是由于来自高阶大脑区域的反馈。目前,这些来源的相对贡献尚不清楚。我们通过记录猕猴V1神经元群体执行涉及相同视觉输入的不同辨别任务来解决这一问题。我们发现rsc的结构(rsc随神经元刺激偏好而变化的方式)随任务指令而系统地改变。因此,即使在皮层视觉层级的最早阶段,任务执行过程中的rsc结构也主要反映了反馈动态。因此,之前关于RSC如何限制感官处理的建议不需要适用。此外,我们表明,单个神经元的活动和选择之间的相关性取决于任务所涉及的反馈。
The variable responses of sensory neurons tend to be weakly correlated (spike-count correlation, rsc). This is widely thought to reflect noise in shared afferents, in which case rsc can limit the reliability of sensory coding. However, it could also be due to feedback from higher-order brain regions. Currently, the relative contribution of these sources is unknown. We addressed this by recording from populations of V1 neurons in macaques performing different discrimination tasks involving the same visual input. We found that the structure of rsc (the way rsc varied with neuronal stimulus preference) changed systematically with task instruction. Therefore, even at the earliest stage in the cortical visual hierarchy, rsc structure during task performance primarily reflects feedback dynamics. Consequently, previous proposals for how rsc constrains sensory processing need not apply. Furthermore, we show that correlations between the activity of single neurons and choice depend on feedback engaged by the task.
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