Sound-by-sound thalamic stimulation modulates midbrain auditory excitability and relative binaural sensitivity in frogs.
Sound-by-sound thalamic stimulation modulates midbrain auditory excitability and relative binaural sensitivity in frogs.
复制标题
DOI：
10.3389/fncir.2014.00085
复制
发表时间：
2014
影响因子：
3.5
通讯作者：
Farris HE
中科院分区：
文献类型：
--
作者：
Ponnath A;Farris HE
下行电路可以调节听觉处理，使敏感度偏向特定的刺激参数和位置。使用清醒的在体单单位录音，本研究测试是否丘脑电刺激调节听觉兴奋性和相对双耳灵敏度的神经元的两栖动物中脑。此外，通过使用比声刺激更长的电刺激（即，秒）或在逐个声音的基础上（ms）呈现，实验解决了调制的形式是否取决于电刺激的时间结构。长时间电刺激（3-10秒的20 Hz方波脉冲）后，自由场噪声刺激的兴奋性（尖峰/声刺激）下降了32%，但超过600秒后恢复。相比之下，在每个噪声刺激前25 ms使用单个2 ms持续时间的电脉冲的逐声电刺激引起更快和不同形式的调制：调制持续<2 s，并且在不同的细胞中，兴奋性降低，增加或延迟。在细胞内，声音的电刺激的调制效果在不同的声学刺激之间变化，包括不同的雄性叫声，这表明调制是特定于某些刺激属性的。对于双耳单位，调制取决于耳朵的输入，作为声音的电刺激之前，两分声刺激引起不对称的调制效果：灵敏度转移的声音只有一只耳朵，或由不同的相对量为双耳。这导致双耳灵敏度的相对差异发生变化。因此，逐个声音的电刺激揭示了快速和耳特异性（即，偏侧化的）听觉调制，其潜在地适合于在听觉场景中的声音分离期间听觉注意力的转移。
Descending circuitry can modulate auditory processing, biasing sensitivity to particular stimulus parameters and locations. Using awake in vivo single unit recordings, this study tested whether electrical stimulation of the thalamus modulates auditory excitability and relative binaural sensitivity in neurons of the amphibian midbrain. In addition, by using electrical stimuli that were either longer than the acoustic stimuli (i.e., seconds) or presented on a sound-by-sound basis (ms), experiments addressed whether the form of modulation depended on the temporal structure of the electrical stimulus. Following long duration electrical stimulation (3–10 s of 20 Hz square pulses), excitability (spikes/acoustic stimulus) to free-field noise stimuli decreased by 32%, but returned over 600 s. In contrast, sound-by-sound electrical stimulation using a single 2 ms duration electrical pulse 25 ms before each noise stimulus caused faster and varied forms of modulation: modulation lasted <2 s and, in different cells, excitability either decreased, increased or shifted in latency. Within cells, the modulatory effect of sound-by-sound electrical stimulation varied between different acoustic stimuli, including for different male calls, suggesting modulation is specific to certain stimulus attributes. For binaural units, modulation depended on the ear of input, as sound-by-sound electrical stimulation preceding dichotic acoustic stimulation caused asymmetric modulatory effects: sensitivity shifted for sounds at only one ear, or by different relative amounts for both ears. This caused a change in the relative difference in binaural sensitivity. Thus, sound-by-sound electrical stimulation revealed fast and ear-specific (i.e., lateralized) auditory modulation that is potentially suited to shifts in auditory attention during sound segregation in the auditory scene.
登录
查看更多内容
DOI：
10.1007/s00359-003-0467-2
发表时间：
2003-12-01
影响因子：
2.1
作者：
Edwards, CJ;Rose, GJ
通讯作者：
Rose, GJ
DOI：
10.1076/ejom.37.2.182.4753
发表时间：
1999-04-01
期刊：
EUROPEAN JOURNAL OF MORPHOLOGY
影响因子：
--
作者：
Endepols, H;Walkowiak, W
通讯作者：
Walkowiak, W
影响因子：
25
作者：
Fritz, Jonathan B.;David, Stephen V.;Radtke-Schuller, Susanne;Yin, Pingbo;Shamma, Shihab A.
通讯作者：
Shamma, Shihab A.
影响因子：
25
作者：
Bajo VM;Nodal FR;Moore DR;King AJ
通讯作者：
King AJ
影响因子：
2.5
作者：
FENG, AS;LIN, WY
通讯作者：
LIN, WY