The descending corticocollicular pathway mediates learning-induced auditory plasticity.
The descending corticocollicular pathway mediates learning-induced auditory plasticity.
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DOI：
10.1038/nn.2466
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发表时间：
2010-02
影响因子：
25
通讯作者：
King AJ
中科院分区：
文献类型：
--
作者：
Bajo VM;Nodal FR;Moore DR;King AJ
大脑皮层感觉区域的下降投射是大脑中最大的通路之一，这表明它们对于皮层下处理很重要。尽管皮质输入已被证明可以调节丘脑和中脑的神经元反应，但这些变化的行为重要性仍然未知。在听觉系统中，主要的下行通路之一是从皮质第五层锥体细胞到中脑的下丘。我们通过使用发色团靶向激光光解选择性杀死神经元，研究了这些神经元在成年雪貂声音定位的经验依赖性重新校准中的作用。当接受适当的训练时，动物通常会在通过可逆地封闭一只耳朵来改变可用的空间线索后重新学习准确定位声音。然而，消除皮质小球神经元后，这种能力就消失了，而正常的声音定位精度不受影响。因此，这种下降通路的完整性对于学习引起的定位可塑性至关重要。
Descending projections from sensory areas of the cerebral cortex are among the largest pathways in the brain, suggesting that they are important for subcortical processing. Although corticofugal inputs have been shown to modulate neuronal responses in the thalamus and midbrain, the behavioral importance of these changes remains unknown. In the auditory system, one of the major descending pathways is from cortical layer V pyramidal cells to the inferior colliculus in the midbrain. We examined the role of these neurons in experience-dependent recalibration of sound localization in adult ferrets by selectively killing the neurons using chromophore-targeted laser photolysis. When provided with appropriate training, animals normally relearn to localize sound accurately after altering the spatial cues available by reversibly occluding one ear. However, this ability was lost after eliminating corticocollicular neurons, whereas normal sound-localization accuracy was unaffected. The integrity of this descending pathway is therefore critical for learning-induced localization plasticity.
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影响因子：
9.8
作者：
Kacelnik O;Nodal FR;Parsons CH;King AJ
通讯作者：
King AJ
影响因子：
5.3
作者：
Alvarado, Juan Carlos;Stanford, Terrence R.;Stein, Barry E.
通讯作者：
Stein, Barry E.
影响因子：
3.2
作者：
Jiang, W;Jiang, H;Stein, BE
通讯作者：
Stein, BE
DOI：
10.1073/pnas.96.14.8200
发表时间：
1999-07-06
影响因子：
11.1
作者：
Krupa, DJ;Ghazanfar, AA;Nicolelis, MAL
通讯作者：
Nicolelis, MAL
影响因子：
56.9
作者：
Kilgard, MP;Merzenich, MM
通讯作者：
Merzenich, MM