Effects of stress on morphine-elicited locomotor activity in hamsters.
Effects of stress on morphine-elicited locomotor activity in hamsters.
复制标题
应激对吗啡引起的仓鼠运动活动的影响。
DOI：
10.1037//0735-7044.102.2.254
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发表时间：
1988
影响因子：
1.9
通讯作者：
Hang,D
中科院分区：
文献类型：
--
作者：
Schnur,P;Martinez,Y;Hang,D
本研究采用两个实验探讨应激对吗啡诱发的仓鼠自发活动的影响。在实验1中，一半的动物习惯于处理和注射程序（低应激条件），一半不（高应激条件）之前，6天的测试与低剂量（2.5毫克/公斤）的吗啡。在第一个测试日，吗啡引起习惯性动物活动过度，而在非习惯性动物吗啡引起活动减退。处理的影响在整个测试日减少，因此在最后一个测试日，吗啡在习惯和非习惯的动物中引起多动症。在实验2中，噪声应激对由三种剂量的吗啡（2.5，5.0和15毫克/公斤）引起的活动的影响进行了研究。一半的动物在低噪声压力（70 dB）条件下进行测试，另一半在高噪声压力（90 dB）条件下进行测试。结果表明，相对于低应激条件，高应激条件下各剂量吗啡的作用增强。这两个实验都表明，环境应激可以增强仓鼠对外源性阿片给药的反应。此外，该结果与应激诱导内源性阿片样物质释放的假设一致，内源性阿片样物质与外源性阿片样物质相加以确定最终有效剂量。
Two experiments were conducted to investigate the effects of stress on morphine-elicited locomotor activity in hamsters. In Experiment 1, half of the animals were habituated to handling and injection procedures (low-stress condition) and half were not (high-stress condition) prior to 6 days of testing with a low dose (2.5 mg/kg) of morphine. On the first test day, morphine elicited hyperactivity among habituated animals, whereas among nonhabituated animals morphine elicited hypoactivity. The effects of handling diminished across test days, so that on the last test day, morphine elicited hyperactivity in both habituated and nonhabituated animals. In Experiment 2, the effect of a noise stressor on activity elicited by three doses of morphine (2.5, 5.0, and 15 mg/kg) was investigated. Half of the animals were tested under conditions of low noise stress (70 dB), and half were tested under conditions of high noise stress (90 dB). Results indicated that the effects of each dose of morphine were potentiated in the high-stress relative to the low-stress condition. Both experiments demonstrated that environmental stressors can potentiate the response to exogenous opiate administration in hamsters. Moreover, the results are consistent with the hypothesis that stress induces the release of endogenous opioids which summate with exogenous opiates to determine the final effective dose.
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影响因子：
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作者：
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DOI：
--
发表时间：
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期刊：
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影响因子：
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作者：
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