The Environmental Microbiome, Allergic Disease, and Asthma.
The Environmental Microbiome, Allergic Disease, and Asthma.
复制标题
环境微生物组、过敏性疾病和哮喘。
DOI：
10.1016/j.jaip.2022.06.006
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发表时间：
2022-09
影响因子：
9.4
通讯作者：
Lai, Peggy S.
中科院分区：
文献类型：
--
作者：
Kelly, Michael S.;Bunyavanich, Supinda;Phipatanakul, Wanda;Lai, Peggy S.
关键词：
环境微生物组代表了我们在环境中遇到的微生物及其代谢物的全部。越来越多的证据支持环境微生物组在过敏性疾病和哮喘的风险和严重程度中的作用。环境微生物群代表着无所不在的、终生的非自体抗原暴露。在出生到一岁之间的关键时期，我们的早期免疫系统和环境微生物群之间的相互作用有两个后果：我们的个体微生物群由环境微生物组成，我们的免疫系统被训练来耐受哪种抗原。在这段时间里，各种各样的接触似乎在很大程度上起到了保护作用，大大降低了患过敏性疾病和哮喘的风险。随着年龄的增长，我们与环境微生物群的互动也发生了变化。虽然环境微生物组继续对人类微生物组的组成产生影响，但它越来越成为抗原刺激和感染的来源。同样的微生物接触可以防止疾病的发展，但也可能加剧疾病的严重程度。虽然我们已经了解了环境微生物群在过敏性疾病中的重要性，但对于环境、微生物群、免疫系统和疾病之间复杂的相互作用，我们还需要了解更多。
The environmental microbiome represents the entirety of the microbes and their metabolites that we encounter in our environments. A growing body of evidence supports the role of the environmental microbiome in risk for and severity of allergic diseases and asthma. The environmental microbiome represents a ubiquitous, lifelong exposure to non-self antigens. During the critical window between birth and one year of life, interactions between our early immune system and the environmental microbiome have two consequences: our individual microbiome is populated by environmental microbes, and our immune system is trained regarding which antigens to tolerate. During this time, a diversity of exposures appears largely protective, dramatically decreasing the risk of developing allergic diseases and asthma. As we grow older, our interactions with the environmental microbiome change. While it continues to exert influence over the composition of the human microbiome, the environmental microbiome becomes increasingly a source for antigenic stimulation and infection. The same microbial exposure protective against disease development may exacerbate disease severity. While much has been learned about the importance of the environmental microbiome in allergic disease, much more remains to be understood about these complicated interactions between our environment, our microbiome, our immune system and disease.
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DOI：
10.1016/j.trsl.2016.09.003
发表时间：
2017-01
期刊：
Translational research : the journal of laboratory and clinical medicine
影响因子：
--
作者：
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通讯作者：
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影响因子：
30.3
作者：
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通讯作者：
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DOI：
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发表时间：
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期刊：
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影响因子：
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DOI：
10.1073/pnas.1420815112
发表时间：
2015-05-05
影响因子：
11.1
作者：
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通讯作者：
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DOI：
10.1056/nejmoa2023294
发表时间：
2021-04-22
期刊：
The New England journal of medicine
影响因子：
--
作者：
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通讯作者：
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