Microbiome and food allergy.
Microbiome and food allergy.
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DOI：
10.1016/j.trsl.2016.09.003
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发表时间：
2017-01
期刊：
影响因子：
--
通讯作者：
Berin MC
中科院分区：
文献类型：
--
作者：
Blázquez AB;Berin MC
食物过敏是一种常见疾病，影响约 8% 的儿童和 5% 的成人。在过去二十年中，患病率有所增加，表明环境对易感性有重要影响。研究表明，出生方式、接触宠物以及有年长的兄弟姐妹是食物过敏发生的重要风险调节因素。随着发现这些因素显着影响肠道微生物群的组成（众所周知，肠道微生物群在塑造免疫系统中发挥着关键作用），最近的研究开始探讨肠道微生物群在食物过敏发展中的作用。人类队列研究支持食物过敏中存在菌群失调，有限的数据表明这种菌群失调发生在生命早期，即过敏发生之前。动物模型研究清楚地表明，肠道微生物群的组成导致对食物过敏的易感性，并且梭状芽胞杆菌等微生物在食物过敏的发生过程中具有保护作用。我们对食物过敏的微生物调节的理解还处于起步阶段，但该领域的现状支持肠道微生物对易感性的重要贡献。未来的挑战是识别可用于预防或治疗食物过敏的共生微生物。
Food allergy is a common disease affecting approximately 8% of children and 5% of adults. The prevalence has increased over the last two decades, suggesting an important environmental contribution to susceptibility. Studies have identified mode of birth, pet exposure, and having older siblings as being significant risk modifying factors in the development of food allergy. With the discovery that these factors significantly impact the composition of the intestinal microbiome, which is known to play a critical role in shaping the immune system, recent studies have begun to address the role of the intestinal microbiota in the development of food allergy. Studies in human cohorts support a dysbiosis in food allergy, and limited data suggest that this dysbiosis occurs early in life, preceding the onset of sensitization. Studies from animal models have clearly shown that the composition of the intestinal microbiota confers susceptibility to food allergy, and that there are organisms such as Clostridia species that are protective in the development of food allergy. Our understanding of microbial regulation of food allergy is in its nascency, but the state of the field supports an important contribution of intestinal microbes to susceptibility. Challenges going forward are to identify commensal-derived microorganisms that could be used therapeutically to prevent or perhaps treat food allergy.
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DOI：
10.1186/1710-1492-9-15
发表时间：
2013
期刊：
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
影响因子：
--
作者：
Azad MB;Konya T;Maughan H;Guttman DS;Field CJ;Sears MR;Becker AB;Scott JA;Kozyrskyj AL
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Kozyrskyj AL
影响因子：
30.3
作者：
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McCoy KD
影响因子：
17.1
作者：
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Gordon JI
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
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Honda K
DOI：
10.1073/pnas.1002601107
发表时间：
2010-06-29
影响因子：
11.1
作者：
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通讯作者：
Knight, Rob