A Pilot Study to Assess Opportunistic Use of CT-Scan for Osteoporosis Screening in Chronic Pancreatitis.
A Pilot Study to Assess Opportunistic Use of CT-Scan for Osteoporosis Screening in Chronic Pancreatitis.
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一项试点研究，以评估CT扫描用于骨质疏松症筛查的机会性使用。
DOI：
10.3389/fphys.2022.866945
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发表时间：
2022
影响因子：
4
通讯作者：
中科院分区：
文献类型：
--
作者：
目的：CT 扫描通常对慢性胰腺炎 (CP) 患者进行。骨病和骨折在 CP 中得到认可，但没有推荐骨质疏松症筛查指南。评估“机会性”CT 扫描得出的骨密度阈值，以识别 CP 中的骨质疏松症。 方法：回顾性试点队列研究。一年内接受过 CT 扫描和双能 X 射线吸收测定法 (DXA) 的 CP 受试者也被纳入其中。在 L1 水平测量 CT 衍生的骨密度。对年龄和 CT 得出的亨斯菲尔德单位 (HU) 骨密度进行 Pearson 相关分析。使用 HU 在不同骨密度阈值下进行单变量分析来识别骨质疏松症。用受试者工作特征（ROC）曲线下面积（AUC）评估模型的判别能力。测试了几个 HU 阈值。 结果：纳入 27 名 CP 受试者，其中 11 名骨密度正常，12 名骨质减少，4 名 DXA 骨质疏松。平均年龄为 59.9 岁 (SD 13.0)。年龄与 HU 呈负相关（r = -0.519，p = 0.006）。在单变量分析中，CT 衍生的骨密度可预测基于 DXA 的骨质疏松症（优势比 (OR) = 0.97 95% 置信区间 (CI) 0.94–1.00，p = 0.03）。测试了 HU 阈值。 106 HU 的阈值使准确性最大化（AUC 为 0.870）。 结论：CT 扫描可重新用于“机会性”筛查，以排除 CP 中的骨质疏松症。有必要进行更大规模的研究来证实这些结果。
Objectives: CT scans are commonly performed in patients with chronic pancreatitis (CP). Osteopathy and fractures are recognized in CP but no osteoporosis screening guidelines are recommended. “Opportunistic” CT scan-derived bone density thresholds are assessed for identifying osteoporosis in CP. Methods: Retrospective pilot cohort study. CP subjects who had CT scans and dual-energy x-ray absorptiometry (DXA) within 1 year were included. CT-derived bone density was measured at the L1 level. Pearson’s correlation was performed between age and CT-derived bone density in Hounsfield unit (HU). Univariate analysis using HU to identify osteoporosis was performed at various thresholds of bone density. The discriminatory ability of the model was evaluated with the area under the receiver operating characteristic (ROC) curve (AUC). Several HU thresholds were tested. Results: Twenty-seven CP subjects were included, of whom 11 had normal bone density, 12 osteopenia, and four osteoporosis on DXA. The mean age was 59.9 years (SD 13.0). There was a negative correlation of age with HU (r = −0.519, p = 0.006). CT-derived bone density predicted DXA-based osteoporosis in the univariable analysis (Odds Ratio (OR) = 0.97 95% Confidence Interval (CI) 0.94–1.00, p = 0.03). HU thresholds were tested. A threshold of 106 HU maximized the accuracy (AUC of 0.870). Conclusions: CT scan may be repurposed for “opportunistic” screening to rule out osteoporosis in CP. A larger study is warranted to confirm these results.
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影响因子：
3.5
作者：
Barkaoui, Abdelwahed;Ben Kahla, Rabeb;Hambli, Ridha
通讯作者：
Hambli, Ridha
影响因子：
5.3
作者：
Schreiber, Joseph J.;Gausden, Elizabeth B.;Weiland, Andrew J.
通讯作者：
Weiland, Andrew J.
影响因子：
5
作者：
Lee, Scott J.;Anderson, Paul A.;Pickhardt, Perry J.
通讯作者：
Pickhardt, Perry J.
影响因子：
2.6
作者：
Gerety, E. -L.;Hopper, M. A.;Bearcroft, P. W. P.
通讯作者：
Bearcroft, P. W. P.
影响因子：
5
作者：
Lenchik, Leon;Weaver, Ashley A.;Boutin, Robert D.
通讯作者：
Boutin, Robert D.