PCL-PEG copolymer based injectable thermosensitive hydrogels.
PCL-PEG copolymer based injectable thermosensitive hydrogels.
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DOI：
10.1016/j.jconrel.2022.01.035
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发表时间：
2022-03
影响因子：
10.8
通讯作者：
Alexander, Amit
中科院分区：
文献类型：
--
作者：
Dethe, Mithun Rajendra;Prabakaran, A.;Ahmed, Hafiz;Agrawal, Mukta;Roy, Upal;Alexander, Amit
在过去的几十年里，许多刺激响应型水凝胶由于其优异的生物降解性和生物相容性而在生物医学应用中得到了广泛的研究。合成化学和材料科学的发展导致原位刺激响应性水凝胶的出现。在这方面，已经合成了几种合成和天然聚合物，并用于制备温度敏感的原位形成的水凝胶。这可以最好地通过注射使用，因为温度刺激可以触发原位水凝胶凝胶化和溶胀行为。有许多智能聚合物可用于基于原位的温敏可注射水凝胶的配制。其中，聚（ε-己内酯）（PCL）聚合物已被FDA认可并批准用于许多生物医学应用。更具体地，将PCL与聚乙二醇（PEG）偶联以获得两亲性温敏“智能”共聚物（PCL-PEG），以形成快速且可逆的物理凝胶化行为。然而，共聚物的化学结构是决定水溶性、热凝胶化行为、药物释放速率、降解速率和递送多种药物的可能性的关键方面。在这篇综述中，我们重点介绍了典型的PCL-PEG基热敏注射水凝胶在过去十年中的进展，用于组织工程和局部给药应用，以治疗各种疾病。此外，PCL-PEG的分子量对胶凝行为的影响也被严格强调为潜在的制药和生物医学应用的最佳水凝胶性质。
A number of stimuli-responsive-based hydrogels has been widely explored in biomedical applications in the last few decades because of their excellent biodegradability and biocompatibility. The development of synthetic chemistry and materials science leads to the emergence of in situ stimuli-responsive hydrogels. In this regard, several synthetic and natural polymers have been synthesized and utilized to prepare temperature-sensitive in situ forming hydrogels. This could be best used via injections as temperature stimulus could trigger in situ hydrogels gelation and swelling behaviors. There are many smart polymers available for the formulation of the in situ based thermoresponsive injectable hydrogel. Among these, poly (ε-caprolactone) (PCL) polymer has been recognized and approved by the FDA for numerous biomedical applications. More specifically, the PCL is coupled with polyethylene glycol (PEG) to obtain amphiphilic thermosensitive “smart” copolymers (PCL-PEG), to form rapid and reversible physical gelation behavior. However, the chemical structure of the copolymer is a critical aspect in determining water solubility, thermo-gelation behavior, drug release rate, degradation rate, and the possibility to deliver a diverse range of drugs. In this review, we have highlighted the typical PCL-PEG-based thermosensitive injectable hydrogels progress in the last decade for tissue engineering and localized drug delivery applications to treat various diseases. Additionally, the impact of molecular weight of PCL-PEG upon gelling behavior has also been critically highlighted for optimum hydrogels properties for potential pharmaceutical and biomedical applications.
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影响因子：
2.6
作者：
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通讯作者：
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DOI：
10.1007/s10856-007-2004-2
发表时间：
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作者：
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