Psychological and biological resilience modulates the effects of stress on epigenetic aging.
Psychological and biological resilience modulates the effects of stress on epigenetic aging.
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DOI：
10.1038/s41398-021-01735-7
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发表时间：
2021-11-27
影响因子：
6.8
通讯作者：
Sinha R
中科院分区：
文献类型：
--
作者：
Harvanek ZM;Fogelman N;Xu K;Sinha R
我们的社会正经历着比以往任何时候都更大的压力，导致了负面的精神和身体后果。慢性压力与负面的长期健康后果有关，这增加了压力与加速衰老有关的可能性。在这项研究中，我们考察了弹性因素是否会影响与压力相关的生物年龄加速。最近发展起来的“表观遗传时钟”，如GRIMAGE，在预测生物年龄和死亡率方面显示出了很好的效果。在这里，我们在一个社区样本(N = 444)中评估了累积压力、压力生理和韧性对加速老龄化的影响。累积应激与加速爬行(P = 0.0388)和应激相关的肾上腺敏感性(皮质醇/促肾上腺皮质激素比率)和胰岛素抵抗(HOMA)相关。在控制了人口统计学和行为因素后，HOMA与加速朝圣相关(P = 0.0186)。值得注意的是，情绪调节和自我控制的心理弹性因素缓和了这些关系。情绪调节缓和了压力与衰老之间的联系(P = 8.82e−4)，情绪调节越差，压力相关的年龄加速越大，而更强的情绪调节阻止了压力对朝圣的任何显著影响。自我控制缓和了压力和胰岛素抵抗之间的关系(P = 0.00732)，高自我控制使这种关系变得迟钝。在最终的模型中，在那些情绪调节不良的人中，累积压力继续预测额外的朝圣加速，即使考虑了人口统计学、生理学和行为协变量。这些结果表明，在健康人群中，累积应激与表观遗传衰老有关，并且这些关联被生物行为弹性因素改变。
Our society is experiencing more stress than ever before, leading to both negative psychiatric and physical outcomes. Chronic stress is linked to negative long-term health consequences, raising the possibility that stress is related to accelerated aging. In this study, we examine whether resilience factors affect stress-associated biological age acceleration. Recently developed “epigenetic clocks” such as GrimAge have shown utility in predicting biological age and mortality. Here, we assessed the impact of cumulative stress, stress physiology, and resilience on accelerated aging in a community sample (N = 444). Cumulative stress was associated with accelerated GrimAge (P = 0.0388) and stress-related physiologic measures of adrenal sensitivity (Cortisol/ACTH ratio) and insulin resistance (HOMA). After controlling for demographic and behavioral factors, HOMA correlated with accelerated GrimAge (P = 0.0186). Remarkably, psychological resilience factors of emotion regulation and self-control moderated these relationships. Emotion regulation moderated the association between stress and aging (P = 8.82e−4) such that with worse emotion regulation, there was greater stress-related age acceleration, while stronger emotion regulation prevented any significant effect of stress on GrimAge. Self-control moderated the relationship between stress and insulin resistance (P = 0.00732), with high self-control blunting this relationship. In the final model, in those with poor emotion regulation, cumulative stress continued to predict additional GrimAge Acceleration even while accounting for demographic, physiologic, and behavioral covariates. These results demonstrate that cumulative stress is associated with epigenetic aging in a healthy population, and these associations are modified by biobehavioral resilience factors.
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影响因子：
4.4
作者：
Beutel TF;Zwerenz R;Michal M
通讯作者：
Michal M
累积压力和冲动性对吸烟状况的影响。
影响因子：
1.7
作者：
Ansell, Emily B. .;Gu, Peihua;Tuit, Keri;Sinha, Rajita
通讯作者：
Sinha, Rajita
影响因子：
5.7
作者：
Breitling LP;Saum KU;Perna L;Schöttker B;Holleczek B;Brenner H
通讯作者：
Brenner H
影响因子：
3.8
作者：
Guendelman S;Medeiros S;Rampes H
通讯作者：
Rampes H
DOI：
10.1016/j.bbi.2015.12.015
发表时间：
2016-03
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Chen E;Miller GE;Yu T;Brody GH
通讯作者：
Brody GH