Regulatory RNAs in the light of Drosophila genomics.
Regulatory RNAs in the light of Drosophila genomics.
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DOI：
10.1093/bfgp/els033
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发表时间：
2012-09
影响因子：
4
通讯作者：
Marco A
中科院分区：
文献类型：
--
作者：
Marco A
基因调控的许多方面是由RNA分子介导的。然而，直到最近，调节RNA仍然难以捉摸。果蝇中至少有三种类型的小调控RNA：microRNA（miRNAs），piwi相互作用RNA和内源性siRNA。第四类调控RNA包括已知的长非编码RNA，如roX1或bxd。黑腹果蝇基因组的初始测序已经作为研究动物转录谱的支架，揭示了调控RNA的功能和生物发生的复杂性。12个果蝇基因组的比较分析对于microRNA进化的研究至关重要。然而，其他RNA调节因子的比较基因组学受到技术问题的困扰：基因组位点保守性较差，并且经常在异染色质中编码。果蝇基因组测序和群体基因组学的未来发展将继续揭示调控RNA的保护，进化和功能。
Many aspects of gene regulation are mediated by RNA molecules. However, regulatory RNAs have remained elusive until very recently. At least three types of small regulatory RNAs have been characterized in Drosophila: microRNAs (miRNAs), piwi-interacting RNAs and endogenous siRNAs. A fourth class of regulatory RNAs includes known long non-coding RNAs such as roX1 or bxd. The initial sequencing of the Drosophila melanogaster genome has served as a scaffold to study the transcriptional profile of an animal, revealing the complexities of the function and biogenesis of regulatory RNAs. The comparative analysis of 12 Drosophila genomes has been crucial for the study of microRNA evolution. However, comparative genomics of other RNA regulators is confounded by technical problems: genomic loci are poorly conserved and frequently encoded in the heterochromatin. Future developments in genome sequencing and population genomics in Drosophila will continue to shed light on the conservation, evolution and function of regulatory RNAs.
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