Role of 3D Volumetric and Perfusion Imaging for Detecting Early Changes in Pancreatic Adenocarcinoma.
Role of 3D Volumetric and Perfusion Imaging for Detecting Early Changes in Pancreatic Adenocarcinoma.
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DOI：
10.3389/fonc.2021.678617
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发表时间：
2021
影响因子：
4.7
通讯作者：
Von Hoff DD
中科院分区：
文献类型：
--
作者：
Rahmanuddin S;Korn R;Cridebring D;Borazanci E;Brase J;Boswell W;Jamil A;Cai W;Sabir A;Motarjem P;Koay E;Mitra A;Goel A;Ho J;Chung V;Von Hoff DD
在高危人群中，主要缺乏可靠的胰腺癌早期检测方法。这项初步研究的重点是使用时间强度-密度曲线（TIDC）和Marley方程分析，结合3D体积和灌注成像来证明它们作为成像生物标志物的潜力，以帮助早期检测胰腺导管腺癌（PDAC）。采用先进的三维成像软件，对28例不同分期胰腺癌患者的多期CT图像进行定量回顾性和前瞻性研究，以确定肿瘤的灌注和放射密度。TIDC和Marley方程在量化肿瘤侵袭性方面被证明是有用的。静脉期的灌注延迟可能与血管内皮生长因子（VEGF）相关的活性有关，VEGF代表肿瘤的活性部分。患者多期CT三维体积分析显示动脉和静脉灌注明显改变，提示肿瘤侵袭状态。TIDC和3D体积分析可以在确定肿瘤对治疗的反应和识别早期侵袭性方面发挥重要作用。
There is a major shortage of reliable early detection methods for pancreatic cancer in high-risk groups. The focus of this preliminary study was to use Time Intensity-Density Curve (TIDC) and Marley Equation analyses, in conjunction with 3D volumetric and perfusion imaging to demonstrate their potential as imaging biomarkers to assist in the early detection of Pancreatic Ductal Adenocarcinoma (PDAC). A quantitative retrospective and prospective study was done by analyzing multi-phase Computed Tomography (CT) images of 28 patients undergoing treatment at different stages of pancreatic adenocarcinoma using advanced 3D imaging software to identify the perfusion and radio density of tumors. TIDC and the Marley Equation proved useful in quantifying tumor aggressiveness. Perfusion delays in the venous phase can be linked to Vascular Endothelial Growth Factor (VEGF)-related activity which represents the active part of the tumor. 3D volume analysis of the multiphase CT scan of the patient showed clear changes in arterial and venous perfusion indicating the aggressive state of the tumor. TIDC and 3D volumetric analysis can play a significant role in defining the response of the tumor to treatment and identifying early-stage aggressiveness.
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影响因子：
2.1
作者：
Fellner, C.;Prantl, L.;Jung, E. M.
通讯作者：
Jung, E. M.
影响因子：
--
作者：
Longo V;Brunetti O;Gnoni A;Cascinu S;Gasparini G;Lorusso V;Ribatti D;Silvestris N
通讯作者：
Silvestris N
影响因子：
4.3
作者：
Ilic M;Ilic I
通讯作者：
Ilic I
影响因子：
24.5
作者：
Canto MI;Harinck F;Hruban RH;Offerhaus GJ;Poley JW;Kamel I;Nio Y;Schulick RS;Bassi C;Kluijt I;Levy MJ;Chak A;Fockens P;Goggins M;Bruno M;International Cancer of Pancreas Screening (CAPS) Consortium
通讯作者：
International Cancer of Pancreas Screening (CAPS) Consortium
DOI：
10.1007/s11548-019-01991-5
发表时间：
2019-08-01
影响因子：
3
作者：
Nayak, Akash;Kayal, Esha Baidya;Mehndiratta, Amit
通讯作者：
Mehndiratta, Amit