PERIOD2 variants are associated with abdominal obesity, psycho-behavioral factors, and attrition in the dietary treatment of obesity.
PERIOD2 variants are associated with abdominal obesity, psycho-behavioral factors, and attrition in the dietary treatment of obesity.
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时期2变异与腹部肥胖，心理行为因素以及肥胖饮食治疗中的流失有关。
DOI：
10.1016/j.jada.2010.03.017
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发表时间：
2010-06
影响因子：
--
通讯作者：
Ordovas JM
中科院分区：
文献类型：
--
作者：
Garaulet M;Corbalán-Tutau MD;Madrid JA;Baraza JC;Parnell LD;Lee YC;Ordovas JM
本研究的目的是测试生物钟相关基因PERIOD 2（PER 2）多态性与基于地中海饮食的行为减肥计划中倾向于退出的患者的磨损之间的关联。共有454超重/肥胖参与者（女性=380，男性=74），年龄在20至65岁，谁出席了2008年1月至12月的肥胖专科门诊，进行了研究。人体测量，生化和饮食摄入量变量进行了分析。该计划的有效性进行了评估，并考虑了减肥障碍的问卷调查。进行多因素分析和logistic回归模型。结果表明，PER 2基因多态性rs 2304672 C>G和rs 4663302 C>T与腹型肥胖相关（P<0.05）。退出治疗的受试者明显更肥胖，减肥障碍更多（P<0.05）。他们还显示出比完成治疗的人更低的提前计划饮食和经历节食压力的可能性。rs 4663307次要等位基因频率在停药组显著高于成功完成治疗组（P<0.05）。逻辑回归分析显示，rs 2304672 C>G次要等位基因携带者比非携带者有更大的辍学可能性、表现出极度吃零食、经历节食压力、无聊时进食和不吃早餐。PER 2与减肥治疗中的消耗有关，并可能调节进食行为相关的表型。这些发现可能代表了基于基因分型和心理行为特征相结合的个性化医疗保健和营养的一步。
The purpose of this research was to test for association between polymorphisms in the circadian clock–related gene PERIOD2 (PER2) and attrition in patients prone to withdrawal from a behavioral weight-reduction program based on the Mediterranean diet. A total of 454 overweight/obese participants (women=380, men=74), aged 20 to 65 years, who attended outpatient clinics specializing in obesity between January and December 2008, were studied. Anthropometric, biochemical, and dietary-intake variables were analyzed. Effectiveness of the program was assessed, and a questionnaire of barriers to weight loss was considered. Multivariate analysis and logistic regression models were performed. Results indicate that PER2 polymorphisms rs2304672C>G and rs4663302C>T were associated with abdominal obesity (P<0.05). Participants who withdrew from treatment were significantly more obese and had more barriers to lose weight (P<0.05). They also displayed a lower likelihood of planning eating in advance and experiencing stress with dieting than those who completed treatment. Frequency of rs4663307 minor allele was significantly greater in withdrawers than in those who successfully completed treatment (P<0.05). Logistic regression analysis showed that rs2304672 C>G minor allele carriers had a greater probability of dropping out, displaying extreme snacking, experiencing stress with dieting, eating when bored, and skipping breakfast than noncarriers. PER2 is implicated in attrition in weight-loss treatment and may modulate eating-behavior–related phenotypes. These findings could represent a step toward personalized health care and nutrition based on a combination of genotyping and psycho-behavioral characterization.
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影响因子：
30.8
作者：
de Bakker, PIW;Yelensky, R;Altshuler, D
通讯作者：
Altshuler, D
影响因子：
3.2
作者：
Serra-Majem, L;Aranceta, J
通讯作者：
Aranceta, J
DOI：
10.1016/s1050-3862(98)00019-9
发表时间：
1999-02-01
期刊：
GENETIC ANALYSIS-BIOMOLECULAR ENGINEERING
影响因子：
--
作者：
Livak, KJ
通讯作者：
Livak, KJ
影响因子：
3.6
作者：
Marin-Guerrero, A. C.;Gutierrez-Fisac, J. L.;Rodriguez-Artalejo, F.
通讯作者：
Rodriguez-Artalejo, F.
DOI：
10.1002/ajmg.b.20143
发表时间：
2004-04-01
影响因子：
2.8
作者：
Pooley, EC;Fairburn, CG;Harrison, PJ
通讯作者：
Harrison, PJ