Intestinal mucin is a chaperone of multivalent copper
Intestinal mucin is a chaperone of multivalent copper
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肠粘蛋白是多价铜的伴侣
DOI：
10.1016/j.cell.2022.09.021
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发表时间：
2022
期刊：
影响因子：
64.5
通讯作者：
Chacón, Kelly N.
中科院分区：
文献类型：
--
作者：
Reznik, Nava;Gallo, Annastassia D.;Rush, Katherine W.;Javitt, Gabriel;Fridmann-Sirkis, Yael;Ilani, Tal;Nairner, Noa A.;Fishilevich, Simon;Gokhman, David;Chacón, Kelly N.
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Mucus protects the epithelial cells of the digestive and respiratory tracts from pathogens and other hazards. Progress in determining the molecular mechanisms of mucus barrier function has been limited by the lack of high-resolution structural information on mucins, the giant, secreted, gel-forming glycoproteins that are the major constituents of mucus. Here, we report how mucin structures we determined enabled the discovery of an unanticipated protective role of mucus: managing the toxic transition metal copper. Using two juxtaposed copper binding sites, one for Cu2+and the other for Cu1+, the intestinal mucin, MUC2, prevents copper toxicity by blocking futile redox cycling and the squandering of dietary antioxidants, while nevertheless permitting uptake of this important trace metal into cells. These findings emphasize the value of molecular structure in advancing mucosal biology, while introducing mucins, produced in massive quantities to guard extensive mucosal surfaces, as extracellular copper chaperones.
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DOI：
10.1016/j.bbamcr.2012.02.011
发表时间：
2012-09
影响因子：
5.1
作者：
Nevitt, Tracy;Oehrvik, Helena;Thiele, Dennis J.
通讯作者：
Thiele, Dennis J.
影响因子：
3
作者：
VanKlinken, BJW;Oussoren, E;Einerhand, AWC
通讯作者：
Einerhand, AWC
影响因子：
64.5
作者：
Javitt G;Khmelnitsky L;Albert L;Bigman LS;Elad N;Morgenstern D;Ilani T;Levy Y;Diskin R;Fass D
通讯作者：
Fass D
Kβ 价与混合蛋氨酸-组氨酸协调的 Cu(I) 结合蛋白的核心 X 射线发射研究。
影响因子：
4.6
作者：
Martin-Diaconescu,Vlad;Chacón,KellyN;Delgado-Jaime,MarioUlises;Sokaras,Dimosthenis;Weng,Tsu-Chien;DeBeer,Serena;Blackburn,NinianJ
通讯作者：
Blackburn,NinianJ
影响因子：
30.3
作者：
Lopez CA;Skaar EP
通讯作者：
Skaar EP