Intake of Fish and Marine n-3 Polyunsaturated Fatty Acids and Risk of Cardiovascular Disease Mortality: A Meta-Analysis of Prospective Cohort Studies.
Intake of Fish and Marine n-3 Polyunsaturated Fatty Acids and Risk of Cardiovascular Disease Mortality: A Meta-Analysis of Prospective Cohort Studies.
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作者：
Jiang L;Wang J;Xiong K;Xu L;Zhang B;Ma A
之前的流行病学研究调查了鱼类和海洋n-3多不饱和脂肪酸（n-3 PUFA）摄入量与心血管疾病（CVD）死亡风险的关系。然而，结果并不一致。本荟萃分析的目的是通过前瞻性队列研究定量评估海洋n-3 PUFA、鱼类和CVD死亡风险之间的关联。对PubMed、Web of Science、Embase和MEDLINE数据库从数据库建立至2021年5月进行了系统检索。共纳入25项队列研究，2，027，512名参与者和103，734例CVD死亡。结果表明，鱼类消费量与CVD死亡风险呈负相关[相关风险（RR）= 0.91; 95%置信区间（CI）0.85 - 0.98]。较高的海洋n-3 PUFA摄入量与心血管疾病死亡风险降低相关（RR = 0.87; 95%CI：0.85-0.89）。剂量反应分析表明，每天增加20 g鱼摄入量（RR = 0.96; 95% CI：0.94-0.99）或80 mg海洋n-3 PUFA摄入量（RR = 0.96; 95% CI：0.94-0.98），CVD死亡率的风险降低了4%。目前的工作提供的证据表明，鱼类和海洋n-3多不饱和脂肪酸的摄入量与心血管疾病死亡率的风险呈负相关。
Previous epidemiological studies have investigated the association of fish and marine n-3 polyunsaturated fatty acids (n-3 PUFA) consumption with cardiovascular disease (CVD) mortality risk. However, the results were inconsistent. The purpose of this meta-analysis is to quantitatively evaluate the association between marine n-3 PUFA, fish and CVD mortality risk with prospective cohort studies. A systematic search was performed on PubMed, Web of Science, Embase and MEDLINE databases from the establishment of the database to May 2021. A total of 25 cohort studies were included with 2,027,512 participants and 103,734 CVD deaths. The results indicated that the fish consumption was inversely associated with the CVD mortality risk [relevant risk (RR) = 0.91; 95% confidence intervals (CI) 0.85−0.98]. The higher marine n-3 PUFA intake was associated with the reduced risk of CVD mortality (RR = 0.87; 95% CI: 0.85–0.89). Dose-response analysis suggested that the risk of CVD mortality was decreased by 4% with an increase of 20 g of fish intake (RR = 0.96; 95% CI: 0.94–0.99) or 80 milligrams of marine n-3 PUFA intake (RR = 0.96; 95% CI: 0.94–0.98) per day. The current work provides evidence that the intake of fish and marine n-3 PUFA are inversely associated with the risk of CVD mortality.
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影响因子：
5
作者：
GREENLAND, S;LONGNECKER, MP
通讯作者：
LONGNECKER, MP
影响因子：
4.2
作者：
Denissen, Karlijn F. M.;Heil, Sandra G.;Dagnelie, Pieter C.
通讯作者：
Dagnelie, Pieter C.
影响因子：
7.3
作者：
Felau, Sheylla M.;Sales, Lucas P.;Benatti, Fabiana B.
通讯作者：
Benatti, Fabiana B.
DOI：
10.1097/mco.0b013e3283439622
发表时间：
2011-03-01
影响因子：
3.1
作者：
Egert, Sarah;Stehle, Peter
通讯作者：
Stehle, Peter
影响因子：
3.2
作者：
Hautero, Ulla;Poussa, Tuija;Laitinen, Kirsi
通讯作者：
Laitinen, Kirsi