Individual diet has sex-dependent effects on vertebrate gut microbiota.
Individual diet has sex-dependent effects on vertebrate gut microbiota.
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DOI：
10.1038/ncomms5500
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发表时间：
2014-07-29
影响因子：
16.6
通讯作者：
Svanback, Richard
中科院分区：
文献类型：
--
作者：
Bolnick, Daniel I.;Snowberg, Lisa K.;Hirsch, Philipp E.;Lauber, Christian L.;Org, Elin;Parks, Brian;Lusis, Aldons J.;Knight, Rob;Caporaso, J. Gregory;Svanback, Richard
Vertebrates harbour diverse communities of symbiotic gut microbes. Host diet is known to alter microbiota composition, implying that dietary treatments might alleviate diseases arising from altered microbial composition (‘dysbiosis’). However, it remains unclear whether diet effects are general or depend on host genotype. Here we show that gut microbiota composition depends on interactions between host diet and sex within populations of wild and laboratory fish, laboratory mice and humans. Within each of two natural fish populations (threespine stickleback and Eurasian perch), among-individual diet variation is correlated with individual differences in gut microbiota. However, these diet–microbiota associations are sex dependent. We document similar sex-specific diet–microbiota correlations in humans. Experimental diet manipulations in laboratory stickleback and mice confirmed that diet affects microbiota differently in males versus females. The prevalence of such genotype by environment (sex by diet) interactions implies that therapies to treat dysbiosis might have sex-specific effects. Diet variations can alter gut microbial composition, but the potential influence of host genetic factors on these effects is unclear. Here, the authors show, in humans and in natural and laboratory fish populations, that such effects are dependent on the host’s sex, a genetically determined factor.
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DOI：
10.1038/ismej.2012.8
发表时间：
2012-08
期刊：
The ISME journal
影响因子：
--
作者：
通讯作者：
--
DOI：
10.1126/science.1224203
发表时间：
2012-06-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Costello EK;Stagaman K;Dethlefsen L;Bohannan BJ;Relman DA
通讯作者：
Relman DA
影响因子：
2.7
作者：
Araujo, Marcio S.;Bolnick, Daniel I.;dos Reis, Sergio F.
通讯作者：
dos Reis, Sergio F.
DOI：
10.1111/j.1095-8312.2008.00978.x
发表时间：
2008-06-01
影响因子：
1.9
作者：
Bolnick, Daniel I.;Caldera, Eric J.;Matthews, Blake
通讯作者：
Matthews, Blake
DOI：
10.1073/pnas.0807920105
发表时间：
2008-11-18
影响因子：
11.1
作者：
Fierer, Noah;Hamady, Micah;Knight, Rob
通讯作者：
Knight, Rob