Exercise Training Increases Resting Calf Muscle Oxygen Metabolism in Patients with Peripheral Artery Disease.
Exercise Training Increases Resting Calf Muscle Oxygen Metabolism in Patients with Peripheral Artery Disease.
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运动训练可增加周围动脉疾病患者的静息小腿肌肉氧代谢
DOI：
10.3390/metabo11120814
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发表时间：
2021-11-29
期刊：
影响因子：
4.1
通讯作者：
Baker WB
中科院分区：
文献类型：
--
作者：
Li Z;Englund EK;Langham MC;Feng J;Jia K;Floyd TF;Yodh AG;Baker WB
Exercise training can mitigate symptoms of claudication (walking-induced muscle pain) in patients with peripheral artery disease (PAD). One adaptive response enabling this improvement is enhanced muscle oxygen metabolism. To explore this issue, we used arterial-occlusion diffuse optical spectroscopy (AO-DOS) to measure the effects of exercise training on the metabolic rate of oxygen (MRO2) in resting calf muscle. Additionally, venous-occlusion DOS (VO-DOS) and frequency-domain DOS (FD-DOS) were used to measure muscle blood flow (F) and tissue oxygen saturation (StO2), and resting calf muscle oxygen extraction fraction (OEF) was calculated from MRO2, F, and blood hemoglobin. Lastly, the venous/arterial ratio (γ) of blood monitored by FD-DOS was calculated from OEF and StO2. PAD patients who experience claudication (n = 28) were randomly assigned to exercise and control groups. Patients in the exercise group received 3 months of supervised exercise training. Optical measurements were obtained at baseline and at 3 months in both groups. Resting MRO2, OEF, and F, respectively, increased by 30% (12%, 44%) (p < 0.001), 17% (6%, 45%) (p = 0.003), and 7% (0%, 16%) (p = 0.11), after exercise training (median (interquartile range)). The pre-exercise γ was 0.76 (0.61, 0.89); it decreased by 12% (35%, 6%) after exercise training (p = 0.011). Improvement in exercise performance was associated with a correlative increase in resting OEF (R = 0.45, p = 0.02).
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影响因子：
5.4
作者：
Gardner AW;Parker DE;Montgomery PS;Blevins SM
通讯作者：
Blevins SM
影响因子：
9.6
作者：
CHEATLE, TR;POTTER, LA;SCURR, JH
通讯作者：
SCURR, JH
影响因子：
15.9
作者：
KETY, SS;SCHMIDT, CF
通讯作者：
SCHMIDT, CF
影响因子：
--
作者：
CHANCE, B;DAIT, MT;HAGERMAN, F
通讯作者：
HAGERMAN, F
影响因子：
2.2
作者：
Benni PB;MacLeod D;Ikeda K;Lin HM
通讯作者：
Lin HM