Monitoring human babesiosis emergence through vector surveillance New England, USA.

Monitoring human babesiosis emergence through vector surveillance New England, USA.
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DOI:
10.3201/eid2002.130644
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发表时间:
2014-02
影响因子:
11.8
通讯作者:
Krause PJ
Krause PJ
中科院分区:
医学2区
文献类型:
--
作者:
Diuk-Wasser MA;Liu Y;Steeves TK;Folsom-O'Keefe C;Dardick KR;Lepore T;Bent SJ;Usmani-Brown S;Telford SR 3rd;Fish D;Krause PJ

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这种监测可以为该病的出现提供早期预警,并衡量疾病漏报情况。人类巴贝斯虫病是一种由红细胞内原生动物微巴贝斯虫引起的新发蜱传疾病。它的地理分布比莱姆病更有限,尽管有相同的蜱虫媒介和宿主。巴贝斯虫病的地理范围正在扩大,但对其范围的了解是不完整的,并且完全依赖于人类病例的报告。我们通过比较人类和蜱的两种感染在不同微蜱流行地区的比例,评估了基于蜱的监测在监测疾病扩展方面的效用。我们发现,在长期建立的巴贝虫病流行地区,人类疾病与蜱虫感染率密切相关,但在新的疾病流行地区,根据蜱虫感染率,人类巴贝虫病的发病率低于预期。这一发现表明,巴贝斯虫病在新兴地点被低估了。基于媒介的监测可为人类巴贝斯虫病的出现提供早期预警系统。
Such surveillance can provide an early warning for emergence of this disease and measure disease underreporting. Human babesiosis is an emerging tick-borne disease caused by the intraerythrocytic protozoan Babesia microti. Its geographic distribution is more limited than that of Lyme disease, despite sharing the same tick vector and reservoir hosts. The geographic range of babesiosis is expanding, but knowledge of its range is incomplete and relies exclusively on reports of human cases. We evaluated the utility of tick-based surveillance for monitoring disease expansion by comparing the ratios of the 2 infections in humans and ticks in areas with varying B. microti endemicity. We found a close association between human disease and tick infection ratios in long-established babesiosis-endemic areas but a lower than expected incidence of human babesiosis on the basis of tick infection rates in new disease-endemic areas. This finding suggests that babesiosis at emerging sites is underreported. Vector-based surveillance can provide an early warning system for the emergence of human babesiosis.
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