Dietary supply with polyunsaturated fatty acids and resulting maternal effects influence host--parasite interactions.
Dietary supply with polyunsaturated fatty acids and resulting maternal effects influence host--parasite interactions.
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DOI：
10.1186/1472-6785-13-41
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发表时间：
2013-10-31
期刊：
影响因子：
--
通讯作者：
Martin-Creuzburg D
中科院分区：
文献类型：
--
作者：
Schlotz N;Ebert D;Martin-Creuzburg D
寄主和寄生虫之间的相互作用基本上可以由寄主营养来调节。多不饱和脂肪酸(PUFAs)是必需的膳食营养素，作为细胞膜的结构成分和二十烷基类化合物的前体，它们是不可或缺的，它们是作用于生殖和免疫的信号分子。在这里，我们利用一个成熟的无脊椎动物宿主-寄生虫系统，淡水食草性大型水蚤及其细菌寄生虫巴氏杆菌，探索了饮食中多不饱和脂肪酸影响寄生虫感染过程的可能性。使用不同多不饱和脂肪酸组成的天然食物来源，并通过实验改变饮食中花生四烯酸(ARA)和二十碳五烯酸(EPA)的可获得性，我们研究了直接摄入多不饱和脂肪酸对母亲后代的影响以及母亲对多不饱和脂肪酸的影响。我们发现寄主和寄生虫都受到食物质量的影响。取食含C20多不饱和脂肪酸的食物可提高寄主后代产量，并在很大程度上传递给下一代。虽然喂食含有高多不饱和脂肪酸的饮食可以显著降低感染的可能性，但只要母亲的饮食中含有多不饱和脂肪酸，下一代的感染成功率就会增加。我们认为，这种相反的影响是由第二代生殖和免疫之间的权衡引起的。考虑到食物中多不饱和脂肪酸对宿主和寄生虫的直接和母体影响，我们认为宿主和寄生虫的相互作用以及自然条件下的疾病动态取决于食物中多不饱和脂肪酸的可获得性。
Interactions between hosts and parasites can be substantially modulated by host nutrition. Polyunsaturated fatty acids (PUFAs) are essential dietary nutrients; they are indispensable as structural components of cell membranes and as precursors for eicosanoids, signalling molecules which act on reproduction and immunity. Here, we explored the potential of dietary PUFAs to affect the course of parasitic infections using a well-established invertebrate host – parasite system, the freshwater herbivore Daphnia magna and its bacterial parasite Pasteuria ramosa. Using natural food sources differing in their PUFA composition and by experimentally modifying the availability of dietary arachidonic acid (ARA) and eicosapentaenoic acid (EPA) we examined PUFA-mediated effects resulting from direct consumption as well as maternal effects on offspring of treated mothers. We found that both host and parasite were affected by food quality. Feeding on C20 PUFA-containing food sources resulted in higher offspring production of hosts and these effects were conveyed to a great extent to the next generation. While feeding on a diet containing high PUFA concentrations significantly reduced the likelihood of becoming infected, the infection success in the next generation increased whenever the maternal diet contained PUFAs. We suggest that this opposing effect was caused by a trade-off between reproduction and immunity in the second generation. Considering the direct and maternal effects of dietary PUFAs on host and parasite we propose that host – parasite interactions and thus disease dynamics under natural conditions are subject to the availability of dietary PUFAs.
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影响因子：
2.7
作者：
Frost, Paul C.;Ebert, Dieter;Zalewski, Alexandra
通讯作者：
Zalewski, Alexandra
影响因子：
8.8
作者：
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通讯作者：
Caceres, Carla E.
DOI：
10.1098/rspb.2012.0509
发表时间：
2012-08-22
影响因子：
4.7
作者：
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通讯作者：
Ebert, Dieter
影响因子：
2.9
作者：
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通讯作者：
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影响因子：
5.4
作者：
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通讯作者：
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