Dorsal striatial hypoconnectivity predicts antipsychotic medication treatment response in first-episode psychosis and unmedicated patients with schizophrenia.
Dorsal striatial hypoconnectivity predicts antipsychotic medication treatment response in first-episode psychosis and unmedicated patients with schizophrenia.
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DOI：
10.1002/brb3.2625
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发表时间：
2022-11
影响因子：
3.1
通讯作者：
Lahti, Adrienne C.
中科院分区：
文献类型：
--
作者：
Nelson, Eric A.;Kraguljac, Nina, V;Maximo, Jose O.;Armstrong, William;Lahti, Adrienne C.
关键词：
背侧纹状体由尾状核和壳核组成，与精神病谱系障碍的病理生理学有关。由于纹状体中多巴胺受体的浓度很高，纹状体多巴胺失衡可能是皮质-纹状体连接障碍的原因。有很大的兴趣，了解纹状体异常之间的关系，精神病和抗精神病药物治疗反应，但很少有研究认为差异参与的尾状核和壳核。这项研究的目标是双重的。首先，确定模式的背侧纹状体连接障碍的尾状核和壳核分别在精神病谱系障碍患者;其次，确定这些连接障碍模式是否预测治疗反应。使用静息状态功能连接，我们在两个受试者队列中使用单独的双侧尾状核和壳核种子区评估了背侧纹状体连接：一个队列的71名首次用药的精神病患者和一个队列的42名未用药的精神分裂症患者（沿着匹配的对照）。对比每个队列的患者和对照连接图。利培酮治疗6周后，计算患者的临床反应。我们使用回归分析来确定基线连接障碍和治疗反应之间的关系。这种连接障碍也可预测两个队列的治疗应答。这些发现表明，在早期皮质-纹状体连接障碍中，尾状核可能比壳核更是一个驱动因素。这项研究表明，在精神病谱系患者中，背侧纹状体和大规模大脑网络之间存在连接障碍，其中尾状核和默认模式网络以及壳核和显着网络区域之间的连接性降低最为突出（在首次发作的精神病患者中最明显）。两个纹状体亚区的基线连接障碍也可预测随后的抗精神病药物治疗反应，其中基线连接异常越大，结局越差。
The dorsal striatum, comprised of the caudate and putamen, is implicated in the pathophysiology of psychosis spectrum disorders. Given the high concentration of dopamine receptors in the striatum, striatal dopamine imbalance is a likely cause in cortico‐striatal dysconnectivity. There is great interest in understanding the relationship between striatal abnormalities in psychosis and antipsychotic treatment response, but few studies have considered differential involvement of the caudate and putamen. This study's goals were twofold. First, identify patterns of dorsal striatal dysconnectivity for the caudate and putamen separately in patients with a psychosis spectrum disorder; second, determine if these dysconnectivity patterns were predictive of treatment response. Using resting state functional connectivity, we evaluated dorsal striatal connectivity using separate bilateral caudate and putamen seed regions in two cohorts of subjects: a cohort of 71 medication‐naïve first episode psychosis patients and a cohort of 42 unmedicated patients with schizophrenia (along with matched controls). Patient and control connectivity maps were contrasted for each cohort. After receiving 6 weeks of risperidone treatment, patients’ clinical response was calculated. We used regression analyses to determine the relationship between baseline dysconnectivity and treatment response. This dysconnectivity was also predictive of treatment response in both cohorts. These findings suggest that the caudate may be more of a driving factor than the putamen in early cortico‐striatal dysconnectivity. This study shows the presence of dysconnectivity between the dorsal striatum and largescale brain networks in psychosis spectrum patients, where reduced connectivity appears most prominent between the caudate and the default mode network as well as the putamen and areas of the salience network (most robustly seen in first episode psychosis patients). Baseline dysconnectivity of both striatal subregions was also predictive of subsequent antipsychotic treatment response, where greater baseline connectivity abnormalities were associated with poorer outcomes.
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影响因子：
4.7
作者：
Cadena, Elyse J.;White, David M.;Lahti, Adrienne C.
通讯作者：
Lahti, Adrienne C.
DOI：
10.1016/j.bpsc.2019.05.017
发表时间：
2019-11-01
影响因子：
5.9
作者：
Karcher, Nicole R.;Rogers, Baxter P.;Woodward, Neil D.
通讯作者：
Woodward, Neil D.
影响因子：
10.5
作者：
Koch, Kathrin;Rus, Oana Georgiana;Schloesser, Ralf G. M.
通讯作者：
Schloesser, Ralf G. M.
影响因子：
5.4
作者：
Cadena EJ;White DM;Kraguljac NV;Reid MA;Lahti AC
通讯作者：
Lahti AC
影响因子：
56.9
作者：
GERFEN, CR;ENGBER, TM;SIBLEY, DR
通讯作者：
SIBLEY, DR