Too much of a good thing: long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity.
Too much of a good thing: long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity.
复制标题
太多的好事是：长期使用水杨酸盐治疗可以增强外部毛细胞功能，但会损害听觉神经活动。
DOI：
10.1016/j.heares.2010.02.010
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发表时间：
2010-06-14
期刊：
影响因子：
2.8
通讯作者：
Salvi, Richard
中科院分区：
文献类型：
--
作者：
Chen, Guang-Di;Kermany, Mohammad Habiby;D'Elia, Alessandra;Ralli, Massimo;Tanaka, Chiemi;Bielefeld, Eric C.;Ding, Dalian;Henderson, Donald;Salvi, Richard
阿司匹林已广泛用于临床。它对听觉功能的副作用，包括听力损失和耳鸣，被认为是暂时的。最近一个有希望的发现是，用高剂量水杨酸盐（阿司匹林的活性成分）长期治疗数周，增强了外毛细胞（OHC）运动蛋白（普雷斯廷）的表达，导致OHC电运动性增强和畸变产物耳声发射（DPOAE）增强。为了跟进这些观察结果，我们进行了两项研究，一项是与年龄相关的听力损失恢复的计划研究，另一项是水杨酸引起的耳鸣的无关研究。给不同品系和年龄的大鼠注射水杨酸盐，剂量为200 mg/kg/天，每周5天，持续3周，或更高剂量水平（250-350 mg/kg/天），每周4天，持续2周。出乎意料的是，虽然增强或持续的DPOAE被认为是永久性的耳蜗复合动作电位（CAP）和听觉脑干反应（ABR）的振幅降低后，经常观察到慢性水杨酸治疗。这些意想不到的，永久水杨酸诱导的神经活动减少的机制进行了讨论。
Aspirin has been extensively used in clinical settings. Its side effects on auditory function, including hearing loss and tinnitus, are considered as temporary. A recent promising finding is that chronic treatment with high-dose salicylate (the active ingredient of aspirin) for several weeks enhances expression of the outer hair cell (OHC) motor protein (prestin), resulting in strengthened OHC electromotility and enhanced distortion product otoacoustic emissions (DPOAE). To follow up on these observations, we carried out two studies, one planned study of age-related hearing loss restoration and a second unrelated study of salicylate-induced tinnitus. Rats of different strains and ages were injected with salicylate at a dose of 200 mg/kg/day for 5 days per week for 3 weeks or at higher dose levels (250–350 mg/kg/day) for 4 days per week for 2 weeks. Unexpectedly, while an enhanced or sustained DPOAE was seen, permanent reductions in the amplitude of the cochlear compound action potential (CAP) and the auditory brainstem response (ABR) were often observed after the chronic salicylate treatment. The mechanisms underlying these unexpected, permanent salicylate-induced reductions in neural activity are discussed.
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DOI：
10.1017/s0022215100067852
发表时间：
1967-08-01
期刊：
The Journal of laryngology and otology
影响因子：
--
作者：
Bernstein, J M;Weiss, A D
通讯作者：
Weiss, A D
影响因子：
2.5
作者：
Huang, ZW;Luo, YY;Zhao, HB
通讯作者：
Zhao, HB
影响因子：
2.8
作者：
Chen, Guang-Di;Li, Manna;Henderson, Donald
通讯作者：
Henderson, Donald
影响因子：
3.9
作者：
GUNTHER, T;REBENTISCH, E;ISING, H
通讯作者：
ISING, H
影响因子：
2.4
作者：
Janssen, T;Boege, P;Arnold, W
通讯作者：
Arnold, W