Maternal Metabolome in Pregnancy and Childhood Asthma or Recurrent Wheeze in the Vitamin D Antenatal Asthma Reduction Trial.
Maternal Metabolome in Pregnancy and Childhood Asthma or Recurrent Wheeze in the Vitamin D Antenatal Asthma Reduction Trial.
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DOI：
10.3390/metabo11020065
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发表时间：
2021-01-23
期刊：
影响因子：
4.1
通讯作者：
Lasky-Su J
中科院分区：
文献类型：
--
作者：
Huang M;Kelly RS;Chu SH;Kachroo P;Gürdeniz G;Chawes BL;Bisgaard H;Weiss ST;Lasky-Su J
怀孕期间子宫内的环境对儿童的发育健康有重要影响。我们的目的是研究母体代谢组在怀孕的两个不同时间点对后代早期呼吸系统健康的潜在影响。在685对来自维生素D孕妇哮喘减少试验的母亲-儿童对中，我们评估了基线（妊娠10-18周）和妊娠晚期（妊娠32-38周）母体代谢物与3岁儿童哮喘或复发性喘息风险之间的前瞻性关联，使用逻辑回归模型解释混杂因素。按儿童性别进行亚组分析。在632种代谢物中，基线和妊娠晚期分别有19种（3.0%）和62种（9.8%）与结局相关（p值< 0.05）。母体代谢组中与咖啡相关的代谢物似乎特别重要。咖啡因、茶碱、胡芦巴碱、奎尼酸盐和硫酸3-羟基吡啶在至少一个时间点与哮喘风险呈负相关。其他观察结果也强调了类固醇和鞘脂代谢物的作用。总的来说，怀孕后期代谢组与后代哮喘风险之间存在更强的关系。我们的研究结果表明，产前代谢物的改变可能是后代哮喘发展的驱动因素。
The in utero environment during pregnancy has important implications for the developing health of the child. We aim to examine the potential impact of maternal metabolome at two different timepoints in pregnancy on offspring respiratory health in early life. In 685 mother-child pairs from the Vitamin D Antenatal Asthma Reduction Trial, we assessed the prospective associations between maternal metabolites at both baseline (10–18 weeks gestation) and third trimester (32–38 weeks gestation) and the risk of child asthma or recurrent wheeze by age three using logistic regression models accounting for confounding factors. Subgroup analyses were performed by child sex. Among 632 metabolites, 19 (3.0%) and 62 (9.8%) from baseline and third trimester, respectively, were associated with the outcome (p-value < 0.05). Coffee-related metabolites in the maternal metabolome appeared to be of particular importance. Caffeine, theophylline, trigonelline, quinate, and 3-hydroxypyridine sulfate were inversely associated with asthma risk at a minimum of one timepoint. Additional observations also highlight the roles of steroid and sphingolipid metabolites. Overall, there was a stronger relationship between the metabolome in later pregnancy and offspring asthma risk. Our results suggest that alterations in prenatal metabolites may act as drivers of the development of offspring asthma.
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影响因子：
7.4
作者：
Lin H;Levison BS;Buffa JA;Huang Y;Fu X;Wang Z;Gogonea V;DiDonato JA;Hazen SL
通讯作者：
Hazen SL
影响因子：
8.2
作者：
Kadakia, Rachel;Nodzenski, Michael;Lowe, William L., Jr.
通讯作者：
Lowe, William L., Jr.
DOI：
10.1186/s40348-015-0025-3
发表时间：
2015-12
期刊：
Molecular and cellular pediatrics
影响因子：
--
作者：
Ono JG;Worgall TS;Worgall S
通讯作者：
Worgall S
影响因子：
2.6
作者：
Liu, Xiaoqin;Liew, Zeyan;Li, Jiong
通讯作者：
Li, Jiong
影响因子：
9.3
作者：
Chen LW;Wu Y;Neelakantan N;Chong MF;Pan A;van Dam RM
通讯作者：
van Dam RM