Reproducibility of reported nutrient intake and supplement use during a past pregnancy: a report from the Children's Oncology Group.

Reproducibility of reported nutrient intake and supplement use during a past pregnancy: a report from the Children's Oncology Group.
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DOI:
10.1111/j.1365-3016.2009.01070.x
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发表时间:
2010-01
影响因子:
2.8
通讯作者:
Bunin GR
Bunin GR
中科院分区:
医学3区
文献类型:
--
作者:
Bosco JL;Tseng M;Spector LG;Olshan AF;Bunin GR

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母亲的营养和饮食被认为在她的后代的许多情况下都起着作用。使用食物频率问卷(FFQs)的研究报告了与母亲饮食的关系,但这些发现很难解释,因为过去怀孕期间FFQs对饮食的可靠性和有效性尚不清楚。我们确定了一组母亲在过去一次怀孕期间报告的饮食和补充剂使用的重复性,这些母亲接受了一项关于母亲饮食与儿童脑瘤风险的病例对照研究。病例为儿童肿瘤组患者,1991年至1997年6岁时被诊断为髓母细胞瘤或原始神经外胚层瘤。通过随机数字拨号选择与地区代码、种族/民族和出生日期匹配的对照。病例和对照母亲完成了改良的Willett FFQ,平均为孩子出生后五年。平均3.6个月后,由52名病例母亲和51名对照母亲组成的子组母亲重复采访,组成再生性研究人群。仅来自饮食来源的能量调整营养素的平均类内相关性为0.59(范围为0.41,0.69);当包括补充剂时,平均类内相关性为0.41(范围−为0.06,0.70)。根据时间段和模式报告怀孕期间复合维生素使用的一致性良好到非常好(kappa=0.66到0.85)。总体而言,孕期营养评估和补充剂使用的重复性良好,与成人饮食的报告相似。
Maternal nutrition and diet have been suggested to play a role in many conditions of her offspring. Studies using food frequency questionnaires (FFQs) have reported associations with maternal diet, but these findings are difficult to interpret because the reliability and validity of the FFQs for diet during a past pregnancy are not known. We determined the reproducibility of reported diet and supplement use during a past pregnancy in a subset of mothers interviewed for a case-control study of maternal diet in relation to risk of childhood brain tumors. Cases were Children’s Oncology Group patients, diagnosed at age <6 with medulloblastoma or primitive neuroectodermal tumor from 1991–1997. Area code, race/ethnicity, and birth date matched controls were selected by random-digit-dialing. Case and control mothers completed a modified Willett FFQ a mean of five years after the index child’s birth. A mean of 3.6 months later, a subset of mothers consisting of 52 case and 51 control mothers repeated the interview and comprise the reproducibility study population. The mean intra class correlation (ICC) was 0.59 (range 0.41, 0.69) for energy- adjusted nutrients from dietary sources only; it was 0.41 (range −0.06, 0.70) when supplements were included. Agreement for reporting multivitamin use during pregnancy by time period and pattern was good to very good (kappa= 0.66 to 0.85). Overall, the reproducibility of nutrient estimates and supplement use in pregnancy was good and similar to that reported for adult diet.
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