Does gait bout definition influence the ability to discriminate gait quality between people with and without multiple sclerosis during daily life?
Does gait bout definition influence the ability to discriminate gait quality between people with and without multiple sclerosis during daily life?
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DOI：
10.1016/j.gaitpost.2020.11.024
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发表时间：
2021-03
期刊：
影响因子：
2.4
通讯作者：
Horak FB
中科院分区：
文献类型：
--
作者：
Shah VV;McNames J;Harker G;Curtze C;Carlson-Kuhta P;Spain RI;El-Gohary M;Mancini M;Horak FB
在日常生活活动中被动监测步行时，目前尚无关于标准化步态定义的共识。日常生活监测中步态的不同定义如何影响区分病理性步态质量的能力，目前尚不清楚。具体来说，停顿几秒不走路表示一次步态回合的结束和另一次步态回合的开始？在这项研究中，我们研究了3种步态定义对多发性硬化症（MS）患者与健康对照者（HC）在一周日常生活中区分行走质量的能力的影响。15名多发性硬化症患者和16名HC患者在每只脚上穿有仪器的袜子，在下腰椎区域穿一个Opal传感器，每天至少活动8小时。三种步态回合定义基于一次步态回合结束和另一次步态回合开始之间的暂停长度（1.25秒，2.50秒和5.0秒暂停）。曲线下面积（AUC）用于比较MS和HC的步态质量测量。正如预期的那样，在不同的回合定义中，一周的步态回合总数在统计上有显著差异。然而，步态质量测量（如步态速度、步幅、步幅时间）区分MS与HC的auc差异不大。在日常生活中区分MS和HC的步态测量质量不受步态回合长度的影响，尽管不同回合定义的步态数量存在很大差异。因此，MS患者与对照组的步态质量测量可以在使用不同步态定义（暂停长度≤5秒）的研究中进行比较。
There is currently no consensus about standardized gait bout definitions when passively monitoring walking during normal daily life activities. It is also not known how different definitions of a gait bout in daily life monitoring affects the ability to distinguish pathological gait quality. Specifically, how many seconds of a pause with no walking indicates an end to one gait bout and the start of another bout? In this study, we investigated the effect of 3 gait bout definitions on the discriminative ability to distinguish quality of walking in people with multiple sclerosis (MS) from healthy control subjects (HC) during a week of daily living. 15 subjects with MS and 16 HC wore instrumented socks on each foot and one Opal sensor over the lower lumbar area for a week of daily activities for at least 8 h/day. Three gait bout definitions were based on the length of the pause between the end of one gait bout and start of another bout (1.25 s, 2.50 s, and 5.0 s pause). Area under the curve (AUC) was used to compare gait quality measures in MS versus HC. Total number of gait bouts over the week were statistically significantly different across bout definitions, as expected. However, AUCs of gait quality measures (such as gait speed, stride length, stride time) discriminating people with MS from HC were not different despite the 3 bout definitions. Quality of gait measures that discriminate MS from HC during daily life are not influenced by the length of a gait bout, despite large differences in quantity of gait across bout definitions. Thus, gait quality measures in people with MS versus controls can be compared across studies using different gait bout definitions with pause lengths ≤5 s.
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影响因子：
8.6
作者：
Espay, Alberto J.;Hausdorff, Jeffrey M.;Maetzler, Walter
通讯作者：
Maetzler, Walter
影响因子：
5.1
作者：
Shah VV;McNames J;Mancini M;Carlson-Kuhta P;Spain RI;Nutt JG;El-Gohary M;Curtze C;Horak FB
通讯作者：
Horak FB
DOI：
10.1109/titb.2009.2033471
发表时间：
2009-11
期刊：
IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society
影响因子：
--
作者：
Patel S;Lorincz K;Hughes R;Huggins N;Growdon J;Standaert D;Akay M;Dy J;Welsh M;Bonato P
通讯作者：
Bonato P
影响因子：
6
作者：
Shah, Vrutangkumar V.;McNames, James;Horak, Fay B.
通讯作者：
Horak, Fay B.
移动能力实验室（第 2 版）对年轻人、老年人和帕金森病患者步态评估的有效性
影响因子：
3.2
作者：
Morris, Rosie;Stuart, Samuel;Curtze, Carolin
通讯作者：
Curtze, Carolin