Laboratory versus daily life gait characteristics in patients with multiple sclerosis, Parkinson's disease, and matched controls.
Laboratory versus daily life gait characteristics in patients with multiple sclerosis, Parkinson's disease, and matched controls.
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DOI：
10.1186/s12984-020-00781-4
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发表时间：
2020-12-01
影响因子：
5.1
通讯作者：
Horak FB
中科院分区：
文献类型：
--
作者：
Shah VV;McNames J;Mancini M;Carlson-Kuhta P;Spain RI;Nutt JG;El-Gohary M;Curtze C;Horak FB
最近的研究结果表明，在临床或实验室设置离散时刻的步态评估可能不能反映功能，日常活动。为了更好地了解神经系统人群日常生活中的步态，我们比较了在实验室测试中最能区分多发性硬化症（MS）和帕金森病（PD）患者与各自年龄匹配的健康对照受试者（MS- ctl, PD- ctl）的步态测量，以及一周的日常生活监测。我们招募了15名MS患者（年龄平均±SD: 49±10岁）、16名MS- ctl患者（45±11岁）、16名特发性PD患者（71±5岁）和15名PD- ctl患者（69±7岁）。受试者在实验室中佩戴3个惯性传感器（每只脚和下背部各一个），然后在日常生活中佩戴7天。Mann-Whitney U测试和曲线下面积（AUC）比较了PD和PD- ctl、MS和MS- ctl在实验室和日常生活中的差异。参与者在日常生活中佩戴传感器60-68小时。在实验室步态测试和一周的日常生活中，最能区分MS和PD患者步态特征的措施在各自的对照组中是不同的。具体而言，在实验室中，脚趾脱落角度最能区分MS与MS- ctl (AUC [95% CI] = 0.80[0.63-0.96])，而在日常生活中，步态速度（AUC = 0.84[0.69-1.00]）。相比之下，在实验室中，腰椎冠状位运动范围最能区分PD与PD- ctl (AUC = 0.78[0.59-0.96])，而在日常生活中，脚的撞击角度（AUC = 0.84[0.70-0.98]）。与实验室相比，日常生活中的auc更大。与实验室步态测量相比，日常生活步态测量的AUC更大，这表明日常生活监测可能对神经系统疾病的损害更敏感，但每种神经系统疾病可能需要不同的步态结果测量。
Recent findings suggest that a gait assessment at a discrete moment in a clinic or laboratory setting may not reflect functional, everyday mobility. As a step towards better understanding gait during daily life in neurological populations, we compared gait measures that best discriminated people with multiple sclerosis (MS) and people with Parkinson’s Disease (PD) from their respective, age-matched, healthy control subjects (MS-Ctl, PD-Ctl) in laboratory tests versus a week of daily life monitoring. We recruited 15 people with MS (age mean ± SD: 49 ± 10 years), 16 MS-Ctl (45 ± 11 years), 16 people with idiopathic PD (71 ± 5 years), and 15 PD-Ctl (69 ± 7 years). Subjects wore 3 inertial sensors (one each foot and lower back) in the laboratory followed by 7 days during daily life. Mann–Whitney U test and area under the curve (AUC) compared differences between PD and PD-Ctl, and between MS and MS-Ctl in the laboratory and in daily life. Participants wore sensors for 60–68 h in daily life. Measures that best discriminated gait characteristics in people with MS and PD from their respective control groups were different between the laboratory gait test and a week of daily life. Specifically, the toe-off angle best discriminated MS versus MS-Ctl in the laboratory (AUC [95% CI] = 0.80 [0.63–0.96]) whereas gait speed in daily life (AUC = 0.84 [0.69–1.00]). In contrast, the lumbar coronal range of motion best discriminated PD versus PD-Ctl in the laboratory (AUC = 0.78 [0.59–0.96]) whereas foot-strike angle in daily life (AUC = 0.84 [0.70–0.98]). AUCs were larger in daily life compared to the laboratory. Larger AUC for daily life gait measures compared to the laboratory gait measures suggest that daily life monitoring may be more sensitive to impairments from neurological disease, but each neurological disease may require different gait outcome measures.
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影响因子：
3.1
作者：
Mancini M;Horak FB
通讯作者：
Horak FB
影响因子：
--
作者：
Adams, Jamie L;Dinesh, Karthik;Sharma, Gaurav
通讯作者：
Sharma, Gaurav
影响因子：
5.8
作者：
Flachenecker, P;Kümpfel, T;Toyka, K
通讯作者：
Toyka, K
DOI：
10.1097/npt.0b013e318254ba7a
发表时间：
2012-06
期刊：
Journal of neurologic physical therapy : JNPT
影响因子：
--
作者：
Cavanaugh JT;Ellis TD;Earhart GM;Ford MP;Foreman KB;Dibble LE
通讯作者：
Dibble LE
影响因子：
9.9
作者：
Hobart, JC;Riazi, A;Thompson, AJ
通讯作者：
Thompson, AJ