Neonatal melanocortin receptor agonist treatment reduces play fighting and promotes adult attachment in prairie voles in a sex-dependent manner.
Neonatal melanocortin receptor agonist treatment reduces play fighting and promotes adult attachment in prairie voles in a sex-dependent manner.
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DOI：
10.1016/j.neuropharm.2014.05.041
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发表时间：
2014-10
影响因子：
4.7
通讯作者：
Young LJ
中科院分区：
文献类型：
--
作者：
Barrett CE;Modi ME;Zhang BC;Walum H;Inoue K;Young LJ
黑素皮质素受体（melanocortin receptor， MCR）系统在摄食和性行为中的作用已被广泛研究，但对社会行为的影响却很少受到关注。α-MSH与参与社交的神经系统相互作用，包括催产素、多巴胺和阿片系统。急性黑素素- ii （MTII）是一种MC3/4R激动剂，可增强社会一夫一妻制草原田鼠脑后叶催产素（OT）的释放，并促进OT依赖性伴侣偏好的形成。本研究研究了早期MCR刺激对草原田鼠下丘脑神经元活动和社会发展的长期影响。在出生后1-7天，雄性和雌性田鼠每天皮下注射10 mg/kg MTII或生理盐水。与对照组的雄性相比，刚出生时接受治疗的雄性在幼年时表现出了主动玩耍打架的减少。在与异性伴侣短暂同居后，新生儿暴露于MTII促进了成年女性的伴侣偏好形成，而不是男性。当在PND 6-7动物中进行测试时，急性MTII注射引起下丘脑OT、抗利尿激素和促肾上腺皮质激素释放因子神经元中立即早期基因EGR-1免疫反应性的显著爆发。与对照物相比，新生儿每日给予1 mg/kg选择性更强的脑渗透MC4R激动剂PF44687，可促进雌性和雄性的成年伴侣偏好。因此，发育性暴露于MCR激动剂会导致社会行为的持续变化，这表明参与社会关系形成的神经回路发生了结构或功能上的变化。
The melanocortin receptor (MCR) system has been studied extensively for its role in feeding and sexual behavior, but effects on social behavior have received little attention. α-MSH interacts with neural systems involved in sociality, including oxytocin, dopamine, and opioid systems. Acute melanotan-II (MTII), an MC3/4R agonist, potentiates brain oxytocin (OT) release and facilitates OT-dependent partner preference formation in socially monogamous prairie voles. Here we examined the long-term impact of early-life MCR stimulation on hypothalamic neuronal activity and social development in prairie voles. Male and female voles were given daily subcutaneous injections of 10 mg/kg MTII or saline between postnatal days (PND) 1-7. Neonatally-treated males displayed a reduction in initiated play fighting bouts as juveniles compared to control males. Neonatal exposure to MTII facilitated partner preference formation in adult females, but not males, after a brief cohabitation with an opposite-sex partner. Acute MTII injection elicited a significant burst of the immediate early gene EGR-1 immunoreactivity in hypothalamic OT, vasopressin, and corticotrophin releasing factor neurons, when tested in PND 6-7 animals. Daily neonatal treatment with 1 mg/kg of a more selective, brain penetrant MC4R agonist, PF44687, promoted adult partner preferences in both females and males compared with vehicle controls. Thus, developmental exposure to MCR agonists lead to a persistent change in social behavior, suggestive of structural or functional changes in the neural circuits involved in the formation of social relationships.
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影响因子：
2.9
作者：
Carter, C. Sue;Boone, Ericka M.;Bales, Karen L.
通讯作者：
Bales, Karen L.
影响因子：
3
作者：
ACKER, GR;BERRAN, J;STRAND, FL
通讯作者：
STRAND, FL
影响因子：
3.6
作者：
CHAMPNEY, TF;SAHLEY, TL;SANDMAN, CA
通讯作者：
SANDMAN, CA
影响因子：
3
作者：
ARLETTI, R;BENELLI, A;BERTOLINI, A
通讯作者：
BERTOLINI, A
影响因子：
4.1
作者：
Dhillo, WS;Small, CJ;Bloom, SR
通讯作者：
Bloom, SR